Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-592-6 | CAS number: 143-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Environmental Fate/Exposure Summary:
Triethylene glycol monobutyl ether's or
(2-(2-(2-butoxyethoxy)ethoxy)ethanol) production
and use as a plasticizer intermediate, a solvent, in cutting and
hydraulic oils, production of inks, as a leveling agent, in the leather
auxiliaries industry, and in the chemical, textile, and transportation
industries may result in its release to the environment through various
waste streams.
If released to air, a vapor pressure of 2.5X10-3 mm Hg at 25 deg C indicates triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) will exist solely as a vapor in the atmosphere. Vapor-phase triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 7.5 hours.
Alcohols and ethers do not contain chromophores that absorb at wavelengths >290 nm and therefore triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) is not expected to be susceptible to direct photolysis by sunlight.
If released to soil, triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) is expected to have very high mobility based upon an estimated Koc of 10. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 9.5X10-14 atm-cu m/mole. Based on % theoretical BODS of 0-24 in 5-20 days,triethylene glycol monobutyl etheror (2-(2-(2-butoxyethoxy)ethoxy)ethanol) is expected to biodegrade slowly in soil and water.
If released into water, triethylene glycol monobutyl ether or(2-(2-(2-butoxyethoxy)ethoxy)ethanol) is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant.
An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low.
Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions.
Occupational exposure to triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) may occur through inhalation and dermal contact with this compound at workplaces where triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol)is produced or used.
Monitoring and use data indicate that the general population may be exposed to triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) via ingestion of contaminated drinking water and dermal contact with products containing triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol).
Biodegradation
When released to water, some studies show that biodegradation of category members is reasonably rapid (Table 2). OECD guideline studies indicate biodegradability (> 90%) for TGBE ((Triethylene glycol monobutyl ether'sor (2-(2-(2-butoxyethoxy)ethoxy)ethanol)).
However, the APHA comparative biodegradation study of TGBE indicate slower rates of biodegradation (from 47-71%). Altogether, the data suggest that different study methodologies provide variable results for the tri- and tetraethylene glycol ethers.
No category members or surrogates that were tested demonstrate marked resistance to biodegradative processes.
Due to the structural and physical similarities with the other glycol ethers in the category, TetraBE is likely to be biodegradable.
Table 2 Comparison of Biodegradation Rate Ranges for Category Members and Surrogates
Category Member |
Biodegradation Rate Ranges |
TGBE 2-(2-(2-butoxyethoxy)ethoxy)ethanol143-22-6 |
47% after 20 days (APHA) (ready) 88% after 14 day (OECD) (ready) 92% after 21 days (OECD) (ready)** 100% after 9 days (OECD) (inherent) |
TetraME 23783-42-8 |
99% after 8 days (OECD) (inherent)** |
TetraBE 1559-34-8 |
Data for all chemicals are used |
TGME 112-35-6 |
71% after 20 days (APHA) (inherent) |
TGEE 112-50-5 |
71% after 20 days (APHA) (inherent) |
MPEG 350 9004-74-4 |
No data |
DOT4 Brake Fluid |
No data |
Polyethylene glycol monobutyl ether 9004-77-7 |
No data |
Bioaccumulation
This substance has a limited potential to bioaccumulate (based on log Kows ranging from – 1.73 to +0.51@ 20oC), and predicted bioconcentration factors, log BCF = ca. 0.50 (EPIWIN/BCF Program).These values would suggest very low bioaccumulation
potential.
The estimated BCF of 3.162 L/kg wet-wt was measured by calculation from EPI SuiteTM v4.0 Program.
This is Exposure Assessment Tools and Models made from EPA (Environmental Protection Agency).
BCFBAF Program (v3.00) Results:
==============================
SMILES : O(CCOCCOCCO)CCCC
CHEM : Ethanol, 2- 2-(2-butoxyethoxy)ethoxy -
MOL FOR: C10 H22 O4
MOL WT : 206.28
--------------------------------- BCFBAF v3.00 --------------------------------
Summary Results:
Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.0213 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.03 (BAF = 0.944 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 0.02
Equation Used to Make BCF estimate:
Log BCF = 0.50
Correction(s): Value
Correction Factors Not Used for Log Kow < 1
Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt)
Adsorption
2-(2-(2-butoxyethoxy)ethoxy)ethanol does not have a high potential for adsorption to soil due to its fully miscible with water. The Koc of triethylene glycol monobutyl ether or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) can be estimated to be 10 . According to a classification scheme, this estimated Koc value suggests that triethylene glycol monobutyl or (2-(2-(2-butoxyethoxy)ethoxy)ethanol) ether is expected to have very high mobility in soil.
The estimated Soil Adsorption Coefficient was 10 L/kg measured by calculation from EPI SuiteTM v4.0 Program. This is Exposure Assessment Tools and Models made from EPA (Environmental Protection Agency
These results suggest that the2-(2-(2-butoxyethoxy)ethoxy)ethanolhashigh soil mobilityand does not have a high potential for adsorption to soil
KOCWIN Program (v2.00) Results:
==============================
SMILES : O(CCOCCOCCO)CCCC
CHEM : Ethanol, 2- 2-(2-butoxyethoxy)ethoxy -
MOL FOR: C10 H22 O4
MOL WT : 206.28
--------------------------- KOCWIN v2.00 Results ---------------------------
Koc Estimate from MCI:
---------------------
First Order Molecular Connectivity Index ........... : 6.914
Non-Corrected Log Koc (0.5213 MCI + 0.60) .......... : 4.2042
Fragment Correction(s):
1 Aliphatic Alcohol (-C-OH) ........... : -1.3179
3 Ether, aliphatic (-C-O-C-) .......... : -2.6148
Corrected Log Koc .................................. : 0.2715
Over Correction Adjustment to Lower Limit Log Koc ... : 1.0000
Estimated Koc: 10 L/kg <===========
Koc Estimate from Log Kow:
-------------------------
Log Kow (Kowwin estimate) ......................... : 0.02
Non-Corrected Log Koc (0.55313 logKow + 0.9251) .... : 0.9362
Fragment Correction(s):
1 Aliphatic Alcohol (-C-OH) ........... : -0.4114
3 Ether, aliphatic (-C-O-C-) .......... : -0.2718
Corrected Log Koc .................................. : 0.2529
Henry's Law constant
Henry's Law constant The estimated Henrys Law Constant (25 deg C) measured by calculation from EPI SuiteTM v4.1, HENRYWIN v3.20 Program was 2.40E-006 Pa-m3/mole), which is almost zero.
This is Exposure Assessment Tools and Models made from EPA (Environmental Protection Agency).
Bond Est : 2.36E-011 atm-m3/mole(2.40E-006 Pa-m3/mole)
Group Est: 9.52E-014 atm-m3/mole(9.64E-009 Pa-m3/mole)
SMILES : O(CCOCCOCCO)CCCC
CHEM : 2-(2-(2-butoxyethoxy)ethoxy)ethanol
MOL FOR: C10 H22 O4
MOL WT : 206.28
HENRYWIN v3.20 Results
CLASS |
BOND CONTRIBUTION DESCRIPTION |
COMMENT |
VALUE
|
HYDROGEN |
21 Hydrogen to Carbon (aliphatic) Bonds
|
|
-2.5132 |
HYDROGEN |
1 Hydrogen to Oxygen Bonds |
|
3.2318
|
FRAGMENT |
6 C-C |
|
0.6978
|
FRAGMENT |
7 C-O |
|
7.5983
|
RESULT |
BOND ESTIMATION METHOD for LWAPC VALUE |
TOTAL |
9.015
|
HENRYs LAW CONSTANT at 25 deg C = 2.36E-011 atm-m3/mole
= 9.67E-010 unitless
=2.40E-006 Pa-m3/mole
|
GROUP CONTRIBUTION DESCRIPTION |
COMMENT |
VALUE
|
|
1 CH3 (X) |
|
-0.62
|
|
2 CH2 (C)(C) |
|
-0.30 |
|
7 CH2 (C)(O) |
|
-0.91 |
|
1 O-H (C) |
|
4.45
|
|
3 O (C)(C) |
|
8.79
|
RESULT |
GROUP ESTIMATION METHOD for LOG GAMMA VALUE |
TOTAL |
11.41
|
HENRYs LAW CONSTANT at 25 deg C = 9.52E-014 atm-m3/mole
= 3.89E-012 unitless
=9.64E-009 Pa-m3/mole
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.