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Diss Factsheets
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EC number: 203-801-5 | CAS number: 110-76-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable calculation method; the substance is within the applicability domain of the model.
Data source
Referenceopen allclose all
- Reference Type:
- other: Catalogic calculation
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
- Reference Type:
- publication
- Title:
- Base-line model for identifying the bioaccumulation potential of chemicals
- Author:
- Dimitrov S, Dimitrova N, Parkerton T, Comber M, Bonnell M, Mekenyan O
- Year:
- 2 005
- Bibliographic source:
- SAR and QSAR in Environmental Research, 16(6), 1-24
- Reference Type:
- grey literature
- Title:
- Discussion paper for the TC NES subgroup on PBTs. Rep. ACHS/06/11A
- Author:
- Comber M, Robertson S, Sijm DTHM
- Year:
- 2 006
- Bibliographic source:
- EU Commission, Technical Committee on New and Existing Substances (TC NES)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Calculation using Catalogic v.5.11.9.13, BCF base-line model v.02.07
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethoxyethylamine
- EC Number:
- 203-801-5
- EC Name:
- 2-ethoxyethylamine
- Cas Number:
- 110-76-9
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-ethoxyethylamine
Constituent 1
Test conditions
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF:
- Estimation software: OASIS Catalogic v5.11.9.13 [BCF base line model - v.02.07]
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 13.7
- Basis:
- whole body w.w.
- Remarks on result:
- other: considering all mitigating factors; The substance is within the applicability domain of the model.
- Type:
- BCF
- Value:
- 22.3
- Basis:
- whole body w.w.
- Remarks on result:
- other: without considering any mitigating factors; The substance is within the applicability domain of the model.
Any other information on results incl. tables
DOMAIN APPLICABILITY:
With regard to the parametric, structural and mechanistic domain, the test substance is within the applicability domain of the model. Therefore, the estimation is reliable.
MOLECULE SIZE (Maximum diameter) :
- Minimum: 7.96380 Å
- Maximum: 9.82920 Å
- Average: 8.82450 Å
EFFECTS OF MITIGATING FACTORS:
Mitigation factor |
Predicted value |
Magnitude of effect* (as log BCF) |
|
BCF |
Log BCF |
||
Without mitigation |
22.3 |
1.3483 ± 0.000 |
- |
Combination of all factors |
13.7 |
1.1352 ± 0.054 |
0.2133 |
Acids |
0.0000 |
||
Metabolism |
0.0000 |
||
Phenols |
0.0000 |
||
Molecular size |
0.0550 |
||
Water solubility |
0.1756 |
* The magnitude of the effect on the BCF by the single mitigating factors should be regarded as tentative information as the factors influence each other. The effect of individual mitigating factors (e.g. metabolism) is calculated as:
Mitigating effect of metabolism = log BCFcorrected(all factors except for metabolism) – log BCFcorrected(all factors)
RESULTS AND DISCUSSION:
The BCF base-line model estimates the BCF to be 13.7 (log BCF = 1.14) taking all mitigating factors into consideration. The maximum BCF was calculated to be 22.3 (log BCF = 1.35). Mitigating factors like metabolism, molecular size and the water solubility were considered by the model. Water solubility had the highest mitigating effect on the bioaccumulation potential.
According to the OECD 305 technical guidance document, the degree of transformation of the parent is decisive for the effect of metabolism (i.e.. the reproduction of subsequent steps is less critical for the prediction of the BCF).
The model considers several factors, e.g. metabolism, water solubility and molecular size, which have the potential to reduce the log BCF as estimated by the model. Water solubility and molecular size are discussed within the literature whether certain threshold values are suitable as cut-off criteria for indication of limited bioaccumulation. Regarding molecular size, the PBT working group on hazardous substances discussed a maximum diameter of > 17.4 Å (Comber et al., 2006).The maximum diameter of 9.8 Å is lower than the critical value; therefore molecular size has no significant reducing effect on the bioaccumulation potential of the substance.
CONCLUSIONS:
- Water solubility and to a minor extent molecular size reduce the bioaccumulation potential
- The substance is not expected to exhibit a significant bioaccumulation potential
- The substance belongs 100% to the applicability domain of the model.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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