Dichloromethyl(3,3,3-trifluoropropyl)silane

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not reported

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only an abstract was available for review.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

yes

Remarks:

(only 2 animals used, both eyes of the animal were treated (no control), and report not detailed see if housing and feeding conditions were met)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

975-62-7

IUPAC Name:

975-62-7

Constituent 2

Reference substance name:

Dichloromethyl(3,3,3-trifluoropropyl)silane

EC Number:

211-623-4

EC Name:

Dichloromethyl(3,3,3-trifluoropropyl)silane

Cas Number:

675-62-7

Molecular formula:

C4H7Cl2F3Si

IUPAC Name:

(dichloromethyl)(3,3,3-trifluoropropyl)silane

Details on test material:

- Name of test material (as cited in study report): Trifluoropropyl(methyl)dichlorosilane
- Substance type: Chlorosilane
- Physical state: Clear colourless liquid
- Lot/batch No.: TX183A

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino

Details on test animals or tissues and environmental conditions:

Not reported

Test system

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied : 0.1 ml of the undiluted sample

Duration of treatment / exposure:

No data on the single instillation into the eye. One eye of each rabbit was rinsed after 30 seconds of application.

Observation period (in vivo):

1, 24, 48, and 72 hours

Number of animals or in vitro replicates:

2

Details on study design:

REMOVAL OF TEST SUBSTANCE
- Washing (if done): One eye of each rabbit was rinsed for two minutes with tap water. The opposite eye received no further treatment.
- Time after start of exposure: 30 seconds after application.

SCORING SYSTEM: Draize scoring system

Results and discussion

In vivo

Results

Remarks on result:

other: Severe eye irritation was seen in both animals. Conjunctival tissues of all rabbits blanched.

Any other information on results incl. tables

Table 1: Eye irritation scores:

Rabbit No:	Eye	Time (hours)	Cornea		Iris	Conjunctivae			Total score
			Opacity	Area		Erythema	Swelling	Discharge
1	R	1	3	4	- **	0	0	0	60
		24	4	4	-	0	0	0	80
		48	4	4	-	0	0	0	80
		72	4	4	-	0	0	0	82
1	L	1	2	4	0	0	0	0	40
		24	3	4	-	0	1	1	64
		48	3	4	-	0	1	1	64
		72	3	4	-	0	2	1	66
2	R	1	3	4	-	0	2	0	64
		24	4	4	-	0	1	1	84
		48	4	4	-	0	2	1	86
		72	4	4	-	0	2	1	86
2	L	1	3	4	-	0	1	1	64
		24	3	4	-	0	1	1	64
		48	3	4	-	0	2	1	66
		72	3	4	-	0	3	3	72

** Indicates that observation of Iris (all rabbits) not possible due to severity of corneal opacity. Therefore, total score may be greater than shown.

Character of eye irritation: Severe: conjunctival tissues of all rabbits blanched.

Applicant's summary and conclusion

Conclusions:

Severe eye irritation was seen in both animals. Conjunctival tissues of all rabbits blanched.