Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-491-7 | CAS number: 2163-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
1,6-Dichlorohexane was tested in two aquatic tests with algae. The first test was a standard test according to OECD 201. The NOEC-values for both inhibition of growth rate and yield after 72 hours 72 hours were 3.24 mg/L. The LOEC-values for both inhibition of growth rate and yield after 72 hours were 9.80 mg/L. The EC50-values for inhibition of specific growth rate (ErC50) and yield (EyC50) with 95 % confidence intervals after 72 hours were 7.74 (7.20 - 8.14) and 4.84 (3.90 - 7.24) mg/L, respectively.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 7.74 mg/L
- EC10 or NOEC for freshwater algae:
- 3.24 mg/L
Additional information
In the key study, the toxicity of 1,6 -dichlorohexane to the unicellular freshwater green algae Desmodesmus subspicatus was determined according to OECD guideline no. 201. The aim of the study was to assess the effects on growth rate and yield over a period of 72 hours.
The study was conducted under static conditions with an initial cell density of 4332 cells/mL. With regard to the volatility of the test item glass flasks without headspace were used to reduce losses of test item. Based on a preliminary test 7 concentration levels were tested in a geometrical series with a dilution factor of 3.16 (nomimal): 0.10, 0.316, 1.00, 3.16, 10.0, 31.6, 100 mg/L corresponding to initial measured test item concentrations of 0.0282, 0.0991, 0.319, 0.955, 3.24, 9.80, 27.5 mg/L. Three replicates were tested for each test item concentration and six replicates for the control.
The NOEC-values for both inhibition of growth rate and yield after 72 hours 72 hours were 3.24 mg/L. The LOEC-values for both inhibition of growth rate and yield after 72 hours were 9.80 mg/L. The EC50-values for inhibition of specific growth rate (ErC50) and yield (EyC50) with 95 % confidence intervals after 72 hours were 7.74 (7.20 - 8.14) and 4.84 (3.90 - 7.24) mg/L, respectively.
In a further no standard test (supporting study), 1,6 -dichlorohexane was tested to inhibition of assimilation to Scenedesmus Subspicatus for 24 h. The EC 50 (24 h) was 12.9 mg/L. Furthermore the EC 10 and the EC 90 were 4.7 mg/L and 35.3 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)