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Diss Factsheets
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EC number: 242-354-0 | CAS number: 18472-51-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Studies on the acute toxicity of Chlorhexidine digluconate towards terrestrial organisms demonstrated that Chlorhexidine digluconate induced toxic effects at higher concentrations in plants, but not in earthworms or on microbial activity in soil.
Acute toxicity towards plants was tested on Avena sativa (oat), Glycine max (soy bean) and Brassica napus (rape) according to OECD guideline 208. No effects on seedling emergence were observed at the highest concentrations tested (NOECs were always ≥ 1000 mg a.i./kg dry soil). Seedling growth, as determined by shoot fresh-weight and -height, was a more sensitive endpoint display-ing EC50s between 526 and > 1000 mg a.i. /kg dry soil.
In a study according to the OECD guideline 207 on the acute toxicity of Chlorhexidine digluconate towards Eisenia fetida earthworms, the LC50 was determined to be > 1000 mg a.i./kg dry soil (limit test, 1000 mg/kg dry soil of Chlorhexidine digluconate 20%). No effects occurred at this concentration.
There is a study available on the inhibition of microbial activity in soils (nitrogen transformation study) with Chlorhexidine digluconate as test substance. In this study Chlorhexidine digluconate shows no effects after 28 days up to the highest concentration tested (1000 mg test item/kg dry weight corresponding to 193.4 mg a.i/kg dry weight). In addition the tests on the aquatic toxicity tests indicate that microorganisms are less sensitive to Chlorhexidine digluconate than the trophic levels algae, invertebrates and fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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