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Diss Factsheets
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EC number: 217-752-2 | CAS number: 1948-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Data is from experimental study reports
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- An eye irritation study was conducted to determine the eye irritating effects caused by the chemical.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-tert-butylhydroquinone
- EC Number:
- 217-752-2
- EC Name:
- 2-tert-butylhydroquinone
- Cas Number:
- 1948-33-0
- Molecular formula:
- C10-H14-O2
- IUPAC Name:
- 2-tert-butylbenzene-1,4-diol
- Details on test material:
- - Name of test material: 2-tert-butylhydroquinone
- Molecular formula: C10H14O2
- Molecular weight: 166.22
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 14 days
- Observation period (in vivo):
- 1 hr,24 hr,48 hr,7 days and 14 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Hair around eye disc red
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Slight irritation observed for unwashed eye
- Irritation parameter:
- other: cornea appears dry,possible area of necrosis ~ 4mm diameter on conjunctiva
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: for unwashed eye
- Irritation parameter:
- other: watery discharge
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: showed slight irritation for unwashed and washed eye.
- Irritation parameter:
- other: purulent discharge
- Basis:
- mean
- Time point:
- other: 24 hrs. and 48 hrs.
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: slight irritation observed ; unwashed eye
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 days and 14 days
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: for unwashed eye
- Irritant / corrosive response data:
- Residual corneal damage and notched lids present at 14 days.
Any other information on results incl. tables
Summary |
3 Unwashed |
|||||
Immed |
1Hr |
24 Hr |
48Hr |
Day 7 |
Day 14 |
|
Initial |
Slight |
|
|
|
|
|
Conjuctiva |
|
Mod |
Strong |
Mod |
Slight |
|
Lids |
|
Slight |
Slight |
Slight |
Slight |
|
Nict. Membrane |
|
Slight |
Mod |
Slight |
|
|
Corneal capacity |
|
|
Mod |
Mod |
Slight |
Slight |
Iris |
|
|
|
|
|
|
Adnexa stain |
|
|
3/3 |
|
|
|
Corneal stain |
|
|
3/3 |
|
|
|
Number normal |
0/3 |
0/3* |
0/3** |
0/3*** |
2/3 |
2/3 |
Remarks:
* 1hr. – hair around eye disc red – 3/3 slight.
Cornea appears dry, possible area of necrosis ~4mmdiameter on conjuctive -1/3.
Water discharge – 1/3 slight.
** 24 hr. – purulent dischg – 2/3 slight.
*** 48hr. – purulent dischg – 2/3 slight.
7 days – pannus, lids notched – 1/3.
14 hays – pannus, lids notched - /3.
3 Washed |
|||||
Immed |
1Hr |
24Hr |
48Hr |
Day 7 |
Day 14 |
|
|
|
|
|
|
|
Slight |
Slight |
|
|
|
|
|
Slight |
|
|
|
|
Slight |
Slight |
Slight |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2/3 |
|
|
|
|
|
0/3 |
|
|
|
3/3 |
1/3* |
1/3 |
2/3 |
3/3 |
3/3 |
Remarks:
*1 hr – watery dischg – 1/3.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test substance when applied at 1.0 ml concentration to rabbit eye showed moderate to strong eye irritation.
- Executive summary:
The eye irritation study was conducted to determine the adverse eye effects caused by the chemicals.
About 0.1 ml of undiluted test chemical was instilled into the eyes of each rabbit and the eyes were scored at 1 hr,24 hr,48 hr,7 days and 14 days.
The test chemical caused moderate to strong eye irritation, residual corneal damage and notched lid at 14 days. Thus the chemical can be considered as irritating to the eyes of treated rabbits.
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