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EC number: 229-222-8
CAS number: 6440-58-0
Maternal Examinations: No females died, aborted, delivered early or were
removed from the study prior t sacrifice. All females that bore litters
had one or more viable fetuses. No treatment-related clinical signs were
observed during or subsequent to treatment at any dose level. There were
no dose related changes in maternal body weights or body weight changes
throughout gestation. Statistically significant reductions in average
weight gain for days 9-12 at 1000mg/kg/day were not considered to be
related to treatment but rather were considered to reflect stabilization
of body weight in the 1000mg/kg/day group which exhibited a slightly
higher weight gain for days 6-9. There were no differences in body
weight gain at 1000mg/kg/day fro the entire treatment period. There were
no treatment-related effects on food consumption during or subsequent to
dosing. There were no treatment related findings observed at necropsy.
There were no effects on terminal body weight, gravid uterine weight,
corrected body weight, corrected weight change, or relative and absolute
Fetal Examinations: No treatment-related effects on fetal body weights
for male and female were observed in any group. There were no
differences in individual external, visceral or skeletal malformations
by category, or in total malformations among groups. There were no
treatment-related increases in the incidences of individual fetal
external, visceral or skeletal variations by category, or of total
variations among groups. Statistically significant decreases in 1
external variation, excessive bleeding at the umbilicus, and 1 skeletal
variation, majority of proximal phalanges unossified at 1000mg/kg/day
were not considered to be treatment related or biologically significant
due to the lack of a dose-related trend.
DMH is not a developmental toxin.
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