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EC number: 229-222-8
CAS number: 6440-58-0
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for DMDMH and its hydrolysis products and are included in this dossier. As a conservative approach, the most sensitive result across these substances has been taken as the endpoint for DMDMH. The key study, Ciliutti (2003), provides a 48-hr EC50 of 29.1 mg/L for Daphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate endpoint for DMDMH.
(Klimisch 1 or 2) short-term toxicity studies with invertebrates have
been conducted for DMDMH or the hydrolysis product of DMDMH, DMH and are
included in this dossier. Studies conducted with the hydrolysis product,
DMH, are considered relevant for environmental fate and ecotoxicology
and are considered in this dossier.
(2003) conducted a reliable (Klimisch 1) GLP compliant study following
OECD 202 methods. Daphnia magna, <24 hrs old, were exposed to measured
concentrations (61.3, 30.3, 12.7, 6.61 and 2.42 mg/l) of DMDMH in a
semi-static system for 48 hours. The 48hr EC50, based on immobilization,
was 29.1 mg/L.
et al., (1980) conducted a reliable (Klimisch 2) study following methods
for registration of pesticides in the U.S. Daphnia magna were exposed to
nominal concentrations (3000, 5000, 7000, 10000 and 15000 mg/l) of the
hydrolysis product of DMDMH, DMH in a static system for 48 hours. The
48hr EC50, based on immobilization, was 6200 mg/L.
Biotest Laboratories (1982) conducted a reliable (Klimisch 2) study
without following a specified guideline. Daphnia
magna, about 24 hrs old, were exposed to nominal concentrations (10, 18,
32, 56 and 100 mg/l) of DMDMH in a static system for 96 hours. The 96-hr
LC50, based on immobilization, was 37 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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