Registration Dossier
Registration Dossier
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EC number: 252-328-0 | CAS number: 35037-73-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Seven or eight groups of 10 male and 10 female young adult Wister rats (weight 160 - 200 g) each received per gavage a single dose of 100, 1000, 1500, 1750, 2000, 2500, 3000, or 5000 mg/kg bw (male rats) and 100, 500, 1000, 1250, 1500, 2000, or 2500 mg/kg bw (female rats) 4-trifluormethoxyphenyl isocyanate. The animals were observed for mortality and clinical signs through day 14. A gross pathological examination was performed on animals which died during the observation period or were killed after termination of the study.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- p-(trifluoromethoxy)phenyl isocyanate
- EC Number:
- 252-328-0
- EC Name:
- p-(trifluoromethoxy)phenyl isocyanate
- Cas Number:
- 35037-73-1
- Molecular formula:
- C8H4F3NO2
- IUPAC Name:
- 1-isocyanato-4-(trifluoromethoxy)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: acetone/oil 2:10
- Doses:
- male rats: 100, 1000, 1500, 1750, 2000, 2500, 3000, or 5000 mg/kg bw
female rats: 100, 500, 1000, 1250, 1500, 2000, or 2500 mg/kg bw - No. of animals per sex per dose:
- 10 animals /sex/dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 525 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 320 - <= 1 761
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 170 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 906 - <= 2 469
- Mortality:
- The corresponding mortality for male rats was 0% (100 mg/kg bw), 0% (1000 mg/kg bw), 0% (1500 mg/kg bw), 20% (1750 mg/kg bw), 60% (2000 mg/kg bw), 70% (2500 mg/kg bw), 80% (3000 mg/kg bw) and 90% (5000 mg/kg bw) respectively.
The corresponding mortality for female rats was 0% (100 mg/kg bw), 0% (500 mg/kg bw), 0% (1000 mg/kg bw), 20% (1250 mg/kg bw), 40% (1500 mg/kg bw), 90% (2000 mg/kg bw) and 100% (2500 ml/kg bw) respectively. - Other findings:
- necropsy on animals which died during post-observation period: lung spotted, partly slight emphysema, stomach empty, mucosa of forestomach wihite, hardened, intestine with dark, mucous content.
necropsy of animals killed of post-observation period: mucosa of the forestomach showed a slight hardness, other organs without findings
Any other information on results incl. tables
Signs of intoxication: Central nervous effects with laboured breathing, uncoordinated motions, cyanosis, decreased motility and in higher doses aggresivity and partly cramps.
Biginning of symptoms: 15 to 30 minutes in the lower dose groups and 5 to 10 minutes in the letal dose range.
Duration of symptoms: 2 to 6 days
A dose of 100 mg/kg bw was tolerated by male and female rats without symptoms.
The acute oral LD50 for male rats was 2170 mg/kg bw for male rats and 1525 mg/kg bw for female rats
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Based on EU GHS criteria
- Conclusions:
- Signs of intoxication were apathy. decreased motolity, cyanosis, laboured breathing and cramps. The LD50 for female rats was 1525 mg/kg bw and the LD50 for male rats was 2170 mg/kg bw.
- Executive summary:
Seven or eight groups of 10 male and 10 female young adult Wister rats (weight 160 - 200 g) each reveived per gavage a single dose of 100, 1000, 1500, 1750, 2000, 2500, 3000, or 5000 mg/kg bw (male rats) and 100, 500, 1000, 1250, 1500, 2000, or 2500 mg/kg bw (female rats) 4-trifluormethoxyphenyl isocyanate. The animals were observed for mortality and clinical signs through day 14. A gross pathological examination was performed on animals which died during the observation period or were killed after termination of the study.
Signs of intoxication were apathy. decreased motolity, cyanosis, laboured breathing and cramps. The LD50 for female rats was 1525 mg/kg bw and the LD50 for male rats was 2170 mg/kg bw.
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