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EC number: 272-574-2 | CAS number: 68890-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline study but followed scientifically accepted standards and meet many of the requirements of OECD Test Guideline 474.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- no
- Remarks:
- not required at time of testing
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- EC Number:
- 272-574-2
- EC Name:
- 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- Cas Number:
- 68890-66-4
- Molecular formula:
- C14H23NO2.C2H7NO
- IUPAC Name:
- 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICL-ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ICR mice
- Age at study initiation: young adult
- Weight at study initiation: no data
- Assigned to test groups randomly: yes
- Fasting period before study: no data
- Housing: plastic cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: Arabian rubber
- Justification for choice of solvent/vehicle: solubility
- Concentration of test material in vehicle: 2% suspension
- Amount of vehicle (if gavage or dermal): n.a.
- Type and concentration of dispersant aid (if powder): n.a.
- Lot/batch no. (if required): no data
- Purity: no data - Details on exposure:
- Single and repeated (4 day) administration in 2% Arabian rubber solution intraperitoneally. For the single administration, 125, 62.5 and 31.3 mg/kg body weight (1/2, 1/4, and 1/8 of the LD50) were used. For the 4-day repeated administration, four equal portions of 125, 62.5, 31.3 and 15.6 (1/2, 1/4, 1/8, and 1/16 of the LD50) were given for four days.
- Duration of treatment / exposure:
- Intraperitoneal injection
- Frequency of treatment:
- Single and repeated (4 days) treatments
- Post exposure period:
- 24 hours
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
31.3
Basis:
other: 1/8 the LD50 (single application)
- Remarks:
- Doses / Concentrations:
62.5
Basis:
other: 1/4 the LD50 (single application)
- Remarks:
- Doses / Concentrations:
125
Basis:
other: 1/2 the LD50 (single application)
- No. of animals per sex per dose:
- 5 males per group
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Mitomycin C (2.0 mg/kg body weight)
Examinations
- Tissues and cell types examined:
- Femoral bone marrow
- Details of tissue and slide preparation:
- Giemsa smear preparation
- Evaluation criteria:
- number of micronuclei in polychromatic eryhrocytes
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Piroctone olamine is not mutagenic in the micronucleus test - Executive summary:
Piroctone olamine was investigated for the potential to induce chromosomal aberrations in amicronucleus test in ICR male mice. Single and repeated (4 days) administration of Piroctone olamine suspended in 2 % Arabian rubber was given intraperitoneally. The intraperitoneal LD50 in mice was a guide in selecting dose levels. For the single administration, 125, 62.5 and 31.3 mg/kg body weight (approximately 1/2, 1/4 and 1/8 of the LD50, repectively) were used. For the 4 -day repeated administration, four equal portions of 125, 62.5, 31.3 and 15.6 mg/kg body weight (approximately 1/2, 1/4, 1/8 and 1/16 of the LD50) were given daily for four days. 2% Arabian rubber solution was used as the negative control, and the positive control was 2.0 mg/kg body weight mitomycin C. The animals were sacrificed 24 hours after the treatment and the femoral bone marrow was removed for giemsa smear preparation. The incidence of micronucleated cells per 1000 polychromatic erythrocytes per animal was scored. As a result there was no significant increase in the formation of micronuclei in the mouse either in the single or the 4 -day repeated administration, as compared with the negative control. As a result, there was no significant increase in the formation of micronuclei in the mouse polychromatic erythrocytes either in the single or the 4 -day repeated treatment. On the other hand, the group treated with mitomycin C showed a significant increase in micronuclei formation in both, the single as well as the repeated administration. It is concluded that Piroctone olamine has no potential for the induction of chromosome aberrations.
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