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EC number: 235-762-5 | CAS number: 12672-27-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: in-vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP-guideline study - however the conclusion of the test ("A mean IVIS of -0.3690 was calculated, corresponding to a classification as not eye irritant.") is not correct. The BCOP test is an in-vitro test method that can be used to classifiy substances as "ocular corrosives and severe irritants". For identifying non-severe irritants and non-irritants, in-vivo testing needs to take into account.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 437 dated Sept. 2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Straße 7, 55113 Mainz, Germany
Test material
- Reference substance name:
- Aluminum cobalt oxide
- EC Number:
- 235-762-5
- EC Name:
- Aluminum cobalt oxide
- Cas Number:
- 12672-27-4
- Molecular formula:
- Co2Al2.6O4.8 corresponding to two crystalline phases: CoAl2O4 (35%) and Al2Co2O5 (65%)
- IUPAC Name:
- dialuminum; cobalt(2+); oxygen(2-)
- Details on test material:
- - Name of test material (as cited in study report): cobalt aluminium oxide
- Physical state: dark blue powder
- Analytical purity: 99%
- Batch No.: EH 110006/1
- Expiration date of the batch: June 2013
- Storage condition of test material: room temperature
Constituent 1
Test animals / tissue source
- Species:
- other: in-vitro assay
- Strain:
- other: in-vitro assay
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable
- Duration of treatment / exposure:
- not applicable
- Observation period (in vivo):
- not applicable
- Number of animals or in vitro replicates:
- not applicable
Results and discussion
Any other information on results incl. tables
Absorption and opacity values
Parameter |
Negative control |
Test substance |
Positive control |
||||||
Absorption before exposition |
0.1399 |
0.1525 |
0.1113 |
0.1509 |
0.1801 |
0.1504 |
0.1842 |
0.1646 |
0.2069 |
Absorption after exposition |
0.2200 |
0.2820 |
0.1816 |
0.1851 |
0.2362 |
0.2346 |
1.5811 |
1.8850 |
1.5742 |
Opacity before exposition |
1.3799 |
1.4208 |
1.2922 |
1.4154 |
1.5139 |
1.4256 |
1.5282 |
1.4607 |
1.6101 |
Opacity after exposition |
1.6594 |
1.9144 |
1.5192 |
1.5313 |
1.7228 |
1.7163 |
38.1132 |
76.7361 |
37.5155 |
Opacity difference |
0.2795 |
0.4936 |
0.2270 |
0.1159 |
0.2089 |
0.2907 |
36.5850 |
75.2754 |
35.9054 |
Mean opacity difference of the negative control is 0.3334.
Optical density at 490 nm
|
Negative control |
Test substance |
Positive control |
||||||
Meas. |
0.0129 |
0.0140 |
0.0128 |
0.0126 |
0.0145 |
0.0028 |
0.4596 |
0.6091 |
0.7609 |
Corr (x5)* |
0.0643 |
0.0698 |
0.0639 |
0.0632 |
0.0724 |
0.0142 |
2.2979 |
3.0456 |
3.8044 |
Mean |
0.0660 |
- |
|||||||
Corr. – Mean negative control |
-0.0028 |
0.0064 |
-0.0158 |
2.2319 |
2.9796 |
3.7384 |
*In order to correct the path length, a factor of 5 was taken into account when calculating the IVIS.
IVIS values
IVIS was calculated using the values in tables 1 and 2 and the equation stated before:
Test group |
Mean IVIS |
Relative standard deviation IVIS |
Negative control 0.9% NaCl |
1.320 |
14.4% |
Test substance |
-0.3690 |
-110.3% |
Positive control 20% Imidazole |
93.6710 |
26.7% |
Applicant's summary and conclusion
- Interpretation of results:
- other: non corrosive
- Remarks:
- Criteria used for interpretation of results: EU
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