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Diss Factsheets
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EC number: 611-025-7 | CAS number: 53651-69-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- The acute aquatic effect concentration was predicted using an equation developed by the authors, using the log Kow as the predictive variable. The relationship between log Kow and acute aquatic effect concentrations for algae was developed using four different lactates (ethyl lactate, butyl lactate, 2-ethylhexyl lactate, octyl lactate), see table attached as image. The derived equation implies that acute algae toxicity is solely driven by the log Kow. The use of the log Kow as the predictive variable for acute aquatic toxicity was not justified by Bowmer et al. (1998).
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2 400 mg/L
- Basis for effect:
- cell number
- Details on results:
- Based on the equations shown in the table attached as an image, an effect value for growth inhibition based on cell counts were calculated for algae.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- This derivation on basis of the log Kow was not sufficiently justified and thus the predicted ErC50 value of propyl lactate was regarded as not reliable
- Executive summary:
On the basis of equations with the log Kow as the predictive variable, an effect value for growth inhibition based on cell counts was calculated for algae, ErC50 = 2400 mg/L.
The derivation of acute aquatic toxicity on basis of the log Kow was based on seven data points only (measured EC50 values for algae). The approach using the log Kow as the basis for prediction of algal toxicity was not justified by the authors. Therefore, predicted EC50 value of propyl lactate was regarded as not reliable.
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: C(=O)(C(C)O)OCCC
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 177 mg/L
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- The ErC50 for algal growth inhibition by propyl (S)-lactate was estimated by QSAR to be > 100 mg/L.
- Executive summary:
For the determination of the acute toxicity to algae value the 'SciMatics SciQSAR model for acute toxicity to microalgae (72-h growth inhibition, EC50)' as included in the Danish QSAR Database, has been applied. Based on the calculated 72-h ErC50 value of 177 mg/L it can be concluded that propyl (S)-lactate shows very low acute toxicity to algae with an effect value of > 100 mg/L.
Referenceopen allclose all
Description of key information
The 72-h ErC50 of propyl-(S)-lactate for algae is predicted to be 177 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 177 mg/L
Additional information
A recent and valid QSAR calculation (Leadscope, Danish QSAR data base) is used as the key study, resulting in a 72-h ErC50 of 177 mg/L. An older publication, reporting a non-validated simple QSAR model (regression based, scarce data set) is considered unreliable hence used as supportive data only. The corresponding ErC50 is reported to be 2400 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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