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EC number: 203-818-8 | CAS number: 110-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (limited characterisation of test substance, reduced documentation of test animal welfare)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (limited documentation on test substance and test animals)
- Principles of method if other than guideline:
- BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
Test groups consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N,N',N'-tetramethyltrimethylenediamine
- EC Number:
- 203-818-8
- EC Name:
- N,N,N',N'-tetramethyltrimethylenediamine
- Cas Number:
- 110-95-2
- Molecular formula:
- C7H18N2
- IUPAC Name:
- N,N,N',N'-tetramethyltrimethylenediamine
- Details on test material:
- - Name of test material (as cited in study report): Tetramethyl-propylendiamin
- Analytical purity: no data
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Mean weight at study initiation: 189 g (males); 164 g (females)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 8 %
MAXIMUM DOSE VOLUME APPLIED: ca. 15 mL/kg bw - Doses:
- 400, 500, 640, 800, 1000, 1250 µL/kg bw (312, 390, 500, 624, 780, 975 mg/kg bw - based on the density d=0.78 g/cm³)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observation: daily
- Frequency of weighing: days 0, 3, 7 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.8 mL/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 624 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 500 - < 780
- Remarks on result:
- other: based on the density d=0.78 g/cm³
- Mortality:
- 975 mg/kg: 9/10 (2 males and 4 females died within 6 h post application. 3 further males died within 24 h post application.)
780 mg/kg: 7/10 (1 male and 2 females died within 24 h post application. 3 further males and 1 further female died within 7 days post application.)
624 mg/kg: 4/10 (1 female died within 24 h. 2 further females and 1 male died within 7 days.)
500 mg/kg: 1/10 (1 male died within 48 h.)
390 mg/kg: 1/10 (1 female died within 14 days.)
312 mg/kg: 1/10 (1 female died within 48 h.) - Clinical signs:
- other: - 975 and 780 mg/kg: immediately after application: accelerated respiration; 1 h post application: abdominal position, mouth discharge, chewing reflex, in some animals dyspnoea; 3 h post application: red smeared snouts and ruffled fur; 2 days post applica
- Gross pathology:
- Animals that died during observation period: acute passive hyperemia; acute dilatation of the heart; glandular stomach reddened diffusely; isolated ulcerations; diarrhetic contents of the intestines; acinar pattern of the liver
Sacrificed animals: 975 mg/kg: 1x thickened forestomach-epithelium
Any other information on results incl. tables
Mortality:
Dose: (mg/kg) |
Gender |
1 h |
24 h |
48 h |
day 7 |
day 14 |
975 |
male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
975 |
female |
0/5 |
4/5 |
4/5 |
4/5 |
4/5 |
780 |
male |
0/5 |
1/5 |
3/5 |
4/5 |
4/5 |
780 |
female |
0/5 |
2/5 |
2/5 |
3/5 |
3/5 |
624 |
male |
0/5 |
0/5 |
0/5 |
1/5 |
1/5 |
624 |
female |
0/5 |
1/5 |
1/5 |
3/5 |
3/5 |
500 |
male |
0/5 |
0/5 |
1/5 |
1/5 |
1/5 |
500 |
female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
390 |
male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
390 |
female |
0/5 |
0/5 |
0/5 |
0/5 |
1/5 |
312 |
male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
312 |
female |
0/5 |
0/5 |
1/5 |
1/5 |
1/5 |
Weight (g):
Dose (mg/kg) |
Gender |
day 0 |
day 3 |
day 7 |
day 13 |
975 |
male |
168 |
- |
- |
- |
780 |
male |
192 |
171 |
206 |
246 |
624 |
male |
186 |
164 |
184 |
211 |
500 |
male |
194 |
175 |
211 |
231 |
390 |
male |
180 |
174 |
207 |
210 |
312 |
male |
193 |
200 |
229 |
236 |
|
|
|
|
|
|
975 |
female |
163 |
143 |
158 |
159 |
780 |
female |
163 |
149 |
157 |
172 |
624 |
female |
165 |
154 |
149 |
231 |
500 |
female |
164 |
147 |
173 |
173 |
390 |
female |
165 |
146 |
150 |
170 |
312 |
female |
166 |
178 |
168 |
181 |
Harmful if swallowed. There is indication that the test substance causes local irritation to exposed tissue.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The Acute oral toxicity of Tetramethylpropylendiamine (TMPDA) was evaluated in rats according an internal BASF method, which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 Sprague-Dawley rat/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was estimated on the basis of the observed mortalities.
At 975 mg/kg, 2 males and 4 females died within 6 h after treatment. 3 further males died within 24 after treatment.
At 780 mg/kg, 1 male and 2 females died within 24 h after treatment. 4 males and 3 females died within 7 days after treatment.
At 624 mg/kg, 1 female died within 24 h. 3 females and 1 male died within 7 days.
At 500 mg/kg, 1 male died within 48 h.
At 390 mg/kg, 1 female died within 14 days. 312 mg/kg: 1 female died within 48 h.
Under these experimental conditions, the oral LD50 of TMPDA is 624 mg/kg in rats.
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