Registration Dossier
Registration Dossier
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EC number: 202-863-0 | CAS number: 100-54-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, performed under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- Also EC Guideline 96/54/EEC
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Nicotinonitrile
- EC Number:
- 202-863-0
- EC Name:
- Nicotinonitrile
- Cas Number:
- 100-54-9
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-3-carbonitrile
- Reference substance name:
- Pyridine-3-carbonitrile
- IUPAC Name:
- Pyridine-3-carbonitrile
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Hartley HsdPOC: DH
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 0.5 ml
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 0.5 ml
- No. of animals per dose:
- 20
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0.5 ml water
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No erythema or edema
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 0.5 ml water. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No erythema or edema.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0.5 ml water
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No eythema or edema
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 0.5 ml water. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No eythema or edema.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.5 ml
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no erythema or edema
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.5 ml. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no erythema or edema.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.5 ml
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No erythema or edema
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.5 ml. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: No erythema or edema.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- 3-Cyanopyridine was tested in guinea pigs for sensitisation following occlusive dermal exposure. The substance was found to be non-sensitising.
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