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EC number: 447-010-5 | CAS number: 670241-72-2 ISONONYLBENZOAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19. Feb. 2003 - 17. Mar. 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzoic acid isononylester
- Cas Number:
- 670241-72-2
- IUPAC Name:
- Benzoic acid isononylester
- Details on test material:
- Sponsor's identification : Benzoic acid isononylester
Description : Colourless liquid
Batch number : 1276/00576
Date received : 06 January 2003
Storage conditions : Room temperature, in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female Sprague-Dawley Crl:CD® (SD) lOS BR strain rats were supplied by Charles River (UK) Ltd, Margate, Kent. On receipt the animals were randomly allocated to cages. After an acclimatisation period of at least five days the animals were given a number unique within the study by ear punching and a number written on a colour coded cage card. At the start of the study the animals were approximately eight to twelve weeks old and within the weight range of 200g to 350g. The females were nulliparous and non-pregnant.
The animals were housed in groups of five by sex In solid-floor polypropylene cages with stainless steel lids, furnished with softwood flakes (Datesand Ltd., Cheshire, UK) and provided with environmental enrichment items: wooden chew blocks (B & K Universal Ltd, HuIl, UK) and cardboard "fun tunnels" (Datesand Ltd., Cheshire, UK). With the exception of the exposure period, free access to drinking water and food (EU Rodent Diet 5LF2, IPS Limited, Wellingbofough, Northants, UK) was allowed throughout the study. The diet, drinking water, bedding and chew blocks are routinely analysed and are considered not to contain any contaminants that could reasonably be expected to affect the purpose or integrity of the study.
The environmental controls were set to achieve values of 21 ± 2°C and 55 ± 15% relative humidity. The rate of air exchange was at least fifteen changes per hour and the lighting was controlled to give twelve hours continuous light and twelve ho urs darkness. The animals were retained in this accommodation at all times except during the exposure period.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Details on inhalation exposure:
- The test material was aerosolised using a glass concentric jet nebuliser (Radleys, Saffron WaIden, Essex, UK) located at the top of the exposure chamber. The nebuliser was connected to a glass syringe attached to an infusion pump, which provided a continuous supply of test material under
pressure, and to a metered compressed air supply.
Compressed air was supplied by means of an oil free compressor and passed through a water trap and respiratory quality filters before it was introduced to the nebuliser. The cylindrical exposure chamber had a volume of approximately 30 litres (dimensions: 28 cm diameter x 50 cm high). The concentration within the exposure chamber was controlled by adjusting the rate of the infusion pump. The extract from the exposure chamber passed through a 'scrubber' trap and was connected with a high efficiency filter to a metered exhaust system. The chamber was maintained under negative pressure.
Homogeneity of the test atmosphere within the chamber was not specifically determined during this study. Chambers of the same design (ADG Developments Ltd, Hitchin, Herts, UK) have been fully validated and shown to produce evenly distributed atmospheres In the animals breathing zone with a wide variety of test materials. Prior to the start of the study, test material atmospheres were generated within the exposure chamber. During this characterisation period air flow settings and test material input rates were varied to achieve the required atmospheric concentrations. - Duration of exposure:
- 4 h
- Concentrations:
- nominal : 53.9 mg/L
mean measured : 5.22 mg/L - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were observed for clinical signs at hourly intervals during exposure, immediately on
removal from the restraining tubes at the end of exposure, one hour after termination of exposure and subsequently once daily for fourteen days. Any evidence of overt toxicity was rceorded at each observation.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.22 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- There were no death.
- Clinical signs:
- other: Signs of hunched posture, pilo-erection and red/brown staining around the eyes are commonly seen in animals for short periods on removal from the chamber following 4-hour inhalation studies. Wet fur is commonly recorded both during and for a short period
- Body weight:
- Normal bodyweight development was recorded during the study. One female showed reduced bodyweight gain during Week 1 but such variations are not uncommon in female rats of this strain or age and are not considered significant.
- Gross pathology:
- No abnormalities were detected at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information
- Conclusions:
- No deaths occurred in a group often rats exposed to a mean achieved atmosphere concentration of 5.22 mg/L. It was therefore considered that the acute inhalation median lethaI concentration (LC50) of Benzoic acid isononylester, in the Sprague-Dawley Crl:CD® (SD) IGS BR strain rat,
was greater than 5.22 mg/L. - Executive summary:
A study was performed to assess the acute inhalation toxicity of the test material according to OECD 403 "Acute Inhalation Toxicity" referenced as Method B2 in Commission Directive 92/69/EEC "Acute Toxieity - Inhalation" (which constitutes Annex V of Couneil Directive 67/548/EEC).
A group of ten Sprague-Dawley Crl:CD® (SD) IGS BR strain rats (five males and five females) was exposed to an aerosol atmosphere. The animals were exposed far four hours using a no se only exposure system, followed by a fourteen day observation period. No deaths occurred in a group of ten rats exposed to a mean achieved atmosphere concentration of 5.22 mg/L. It was therefore considered that the acute inhalation median lethal concentration (LC50) of Benzoic acid isononylester, in the Sprague-Dawley Crl:CD® (SD) IGS BR strain rat, was greater than 5.22 mg/L.
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