4,8-Dimethyl-2,5,7,10-tetraoxaundecane

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes

Specific details on test material used for the study:

Identification: 4,8-Dimethyl-2,5,7,10-tetraoxaundecane
CAS number: 59039-15-5
Appearance/Physical state: clear colorless liquid
Batch: 1604211010R
Purity: 99.9777%
Expiry / Retest date: 21 April 2017
Storage conditions: approximately 4 °C, in the dark, under nitrogen

Analytical monitoring:

yes

Remarks:

The standard and sample solutions were analyzed by GC.

Buffers:

The test system consisted of buffer solutions at pH’s 4, 7 and 9, detailed below:

Buffer solution (pH): 4
Components (concentration in mmol dm-3 ): Citric acid (6), Sodium chloride (4), Sodium hydroxide (7)

Buffer solution (pH): 7
Components (concentration in mmol dm-3 ): Disodium hydrogen orthophosphate anhydrous (3), Potassium dihydrogen orthophosphate (2), Sodium chloride (2)

Buffer solution (pH): 9
Components (concentration in mmol dm-3 ): Disodium tetraborate (1), Sodium chloride (2)

The buffer solutions were passed through a 0.2 μm membrane filter to sterilize and subjected to ultrasonication and degassing with nitrogen to minimize dissolved oxygen.

Details on test conditions:

Stock solutions of test item were prepared at a nominal concentration of 500 mg/L.
The stock solutions were split into individual glass vessels, sealed with minimal headspace purged with nitrogen, for each data point. These sample solutions were shielded from light whilst maintained at the test temperature.

Duration:

5 d

pH:

9

Temp.:

50 °C

Duration:

5 d

pH:

7

Temp.:

50 °C

Duration:

5 d

pH:

4

Temp.:

50 °C

Number of replicates:

2

Positive controls:

no

Negative controls:

no

Preliminary study:

Less than 10% hydrolysis was observed after 5 days in the preliminary test. The test item is therefore considered hydrolytically stable and, no additional testing was required.Less than 10% hydrolysis was observed after 5 days in the preliminary test. The test item is therefore considered hydrolytically stable and, no additional testing was required.

Transformation products:

no

% Recovery:

> 90

pH:

9

Temp.:

50 °C

Duration:

5 d

% Recovery:

> 90

pH:

7

Temp.:

50 °C

Duration:

5 d

% Recovery:

> 90

pH:

4

Temp.:

50 °C

Duration:

5 d

Key result

pH:

9

Temp.:

50 °C

Remarks on result:

hydrolytically stable based on preliminary test

Key result

pH:

7

Temp.:

50 °C

Remarks on result:

hydrolytically stable based on preliminary test

Key result

pH:

4

Temp.:

50 °C

Remarks on result:

hydrolytically stable based on preliminary test

Details on results:

Less than 10% hydrolysis was observed after 5 days in the preliminary test. The test item is therefore considered hydrolytically stable and, no additional testing was required.Less than 10% hydrolysis was observed after 5 days in the preliminary test. The test item is therefore considered hydrolytically stable and, no additional testing was required.

Validity criteria fulfilled:

yes

Remarks:

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 10 to 100 mg/L. The results were satisfactory with a correlation coefficient (r) of 0.9995 being obtained.

Conclusions:

The half-life of the test item was shown to be greater than 1 year at 25 °C for pH 4, pH 7 and pH 9.

Executive summary:

Less than 10% hydrolysis was observed after 5 days at 50 °C at pH 4, 7 and 9 in the preliminary test. The test item is
therefore considered hydrolytically stable. The half-life of the test item was shown to be greater than 1 year at 25 °C for pH 4, pH 7 and pH 9.

Description of key information

The half-life of the test item was shown to be greater than 1 year at 25 °C for pH 4, pH 7 and pH 9.