Registration Dossier
Registration Dossier
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EC number: 232-576-6 | CAS number: 9001-03-0
Endpoint summary
Administrative data
Description of key information
GLP Daphnia study as selected as read-across from Xanthan lyase. Non-GLP studies are available on Carbonic anhydrase as a supporting studies.
Exposure of Daphnia magna to Xanthan lyase, batch PPE55581 gave EC50 value of greater than 1761.4 mg enzyme concentrate dry matter/L (equivalent to 100 mg aep/L). The No Observed Effect Concentration (NOEC) was the highest concentration tested, 1761.4 mg enzyme concentrate dry matter/L (equivalent to 100 mg aep/L).
Exposure of Daphnia magna to Carbonic anhydraase, batch PPE93985 has been investigated based on nominal concentrations revealed no effect on immobilization. The 48-hour EC50 value was greater than the highest concentration tested 676.6 mg enzyme concentrate dry matter/L (equivalent to 100 mg active enzyme protein/L). The NOEC is 676.6 mg enzyme concentrate dry matter/L (equivalent to 100 mg active enzyme protein/L).
The exposure of R. subcapitata to Carbonic anhydrase, batch PPE93985 was toxic to algae based on its algaestatic, CO2 quenching mode of action. 250 mg sodium bicarbonate and constant shaking were introduced to the test system. 72-hr EC50 was 59.4 mg enzyme concentrate dry matter, equivalent to 8.8 mg active enzyme protein/L. The study is non-GLP and analytical measurements have not been undertaken.
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