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EC number: 427-820-5 | CAS number: 2701-50-0 1,2-METHYLEN-4,6-DIENACETAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June - July 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987-02-24
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 17-acetoxy-1β,2β-methanopegna-4,6-diene-3,20-dione
- EC Number:
- 427-820-5
- EC Name:
- 17-acetoxy-1β,2β-methanopegna-4,6-diene-3,20-dione
- Cas Number:
- 2701-50-0
- Molecular formula:
- C24H30O4
- IUPAC Name:
- (1S,2S,3R,5S,11R,12S,15R,16S)-15-acetyl-2,16-dimethyl-6-oxopentacyclo[9.7.0.0²,⁸.0³,⁵.0¹²,¹⁶]octadeca-7,9-dien-15-yl acetate
- Test material form:
- solid: bulk
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Controls:
- other: left eye served as control
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- test substance remained in the eye, eye was not rinsed
- Observation period (in vivo):
- 11 d
- Number of animals or in vitro replicates:
- 2 males and 2 females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.41
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.41
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
Any other information on results incl. tables
Results of the study after 24, 48 and 72 h:
Irritant Effects (Score) | |||||||
Animal | 24 h | 48 h | 72 h | Mean scores/ animal | |||
429 (M) | Cornea | 0 | 0 | 0 | 0.0 | ||
Iris | 0 | 0 | 0 | 0.0 | |||
Conjunctivae (reddening) | 1 | 0 | 0 | 0.33 | |||
Conjunctivae (swelling) | 0 | 0 | 0 | 0.0 | |||
432 (M) | Cornea | 0 | 0 | 0 | |||
Iris | 0 | 0 | 0 | 0.0 | |||
Conjunctivae (reddening) | 1 | 0 | 0 | 0.33 | |||
Conjunctivae (swelling) | 2 | 1 | 0 | 1.0 | |||
401 (F) | Cornea | 0 | 0 | 0 | 0.0 | ||
Iris | 0 | 0 | 0 | 0.0 | |||
Conjunctivae (reddening) | 0 | 0 | 0 | 0.0 | |||
Conjunctivae (swelling) | 0 | 0 | 0 | 0.0 | |||
422 (F) | Cornea | 0 | 0 | 0 | 0.0 | ||
Iris | 0 | 0 | 0 | 0.0 | |||
Conjunctivae (reddening) | 1 | 1 | 0 | 1.0 | |||
Conjunctivae (swelling) | 3 | 1 | 1 | 1.66 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- not eye irritating
The single application of 100 mg ZK 5.690 into the right eye of rabbits led to irritation which is on the whole judged as slight to moderate. Similar reactions might be expected after inadvertent contact of the human eye with the substance. Since the rabbit eye reacts more sensitively than the human eye due to anatomical and physiological differences, no severe intolerance reactions need to be expected after inadvertent contact of the human eye with ZK 5.690. According to the EU criteria for general classification and labelling requirements for dangerous substances and preparations, however, ZK 5.690 need not be labelled as an eye irritant. - Executive summary:
The local tolerance of ZK 5.690 after a single application of 100 mg of the substance into the conjunctival sac of the right eye was tested in 4 New Zealand White rabbits (2M, 2F).
The respective left eye remained untreated and served as contral. Observations were performed before application, 0.5, 1 and 2 hours thereafter and then once daily until day 11 of the test.
On the day of application, slight to moderate irritation [reddening and swelling of eyelids, conjunctivae and membrana nictitans, and vascular injection of conjunctivae, sclera (only in two animals) .and membrana nictitans] was found in 3 of 4 animals. In one animal (422F) severe swelling of the conjunctiva and moderat~ to severe swelling of the membrana nictitans were observed on the application day, which subsided graduallyon days 2-4.
The animals were without symptoms from day 2 (no. 401 F) or 3 (432M, 429M) onwards.
Animal 422F showed only vascular injection of the membrana nictitans fram day 5 onwards and was without findings from day 9 onwards.
The calculation of mean values of the findings according to the system of evaluation recommended for the EU (Draize) revealed 0 for the parameters cornea and iris and 0.41 for conjunctival reddening and swelling.
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