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EC number: 695-022-6 | CAS number: 473278-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Studies investigating the terrestrial toxicity of tefuryltrione, are available for terrestrial invertebrates and soil microorganisms.
For the assessment of the terrestrial toxicity of tefuryltrione, data on toxicity to earthworms are particularly relevant due to their exposure via different uptake routes (i.e. exposure via soil pore water, ingestion of soil material). The short-term toxicity of the test substance to earthworms (Eisenia fetida) was investigated after 14-day exposure according to OECD guideline 207. The no-observed-effect-concentration (NOEC) with no mortality, no intoxication symptoms and no significant weight decrease compared to the control was ≥1000 mg test item/kg dry artificial soil.
The potential effects of tefuryltrione on nitrogen and carbon transformation of soil microorganisms was investigated using natural soil from an uncultivated site. The studies were performed according to OECD 216 (nitrogen transformation) and 217 (carbon transformation) under GLP conditions. In the study on carbon transformation no inhibition was recorded after 28 d. Thus, the EC10 and NOEC (28 d) were derived to be >4.00 mg/kg soil dw and ≥4.00 mg/kg soil dw, respectively. In the study on nitrogen transformation no inhibition was recorded after 56 days. Thus, the EC10 and NOEC (56 d) were derived to be >4.00 mg/kg soil dw and ≥4.00 mg/kg soil dw, respectively.
Moreover studies on the toxicity of tefuryltrione towards bees and birds are available. The oral toxicity of tefuryltrione to Apis mellifera was assessed (OECD 213) and a 72h LD50 of >95.78 μg substance per bee was determined. The contact toxicity of tefuryltrione to Apis mellifera, was investigated according to OECD 214. The substance was found to have a 72 h contact LD50 of >100 μg substance per bee.
The acute oral and short-term dietary toxicity of tefuryltrione was assessed in the Bobwhite quail (Colinus virginianus, OECD 223 & 205), the Japanese quail (Coturnix coturnix japonica, OECD 223), and Mallard duck (Anas platyrhynchos, OECD 205). Tefuryltrione was of low acute oral and short-term dietary toxicity to Bobwhite quail, Japanese quail and Mallard duck since the acute oral LD50 was >2000 mg/kg body weight in all studies. Moreover, the dietary LC50 was >3980 mg/kg feed for Bobwhite quail and >4213 mg/kg feed for Mallard duck, indicating low short-term toxicity. Beside one premature death, mortalities were observed at 2000 mg a.i./kg bw in the acute oral test with Japanese quail. Therefore, the non-lethal dose (NLD) was at 1734 mg a.i./kg bw.
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