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EC number: 432-770-2 | CAS number: 139189-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
21-day EC50 (concentration causing 50 per cent reduction in reproduction) >0.00077mg/L
21-day LC50 for parent daphnid (median lethal concentration) >0.00077 mg/L
NOEC (no observed effect concentration) >0.00077 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.001 mg/L
Additional information
The objective of this study is to assess the lowest observed effect concentration (LOEC), no observed effect concentration (NOEC), and 50 per cent reduction in reproduction(EC50)if possible by investigating the effect of PX-200 onDaphnidsreproduction.
This study was performed according to the following test methods and guidance document.
Daphnia magnaReproduction Test (Guideline 211, October 3, 2008) described in OECD Guidelines for Testing of Chemicals. OECD Guidance Document No. 23 "Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures" (September 2000).This study was conducted in compliance with the Principles of Good Laboratory Practice (GLP).
This study was conducted as a limit test in order to confirm the reproductive effect of the test item on the test organisms around the solubility of the test item in the dilution water. Since the test item is sparingly soluble in water and water solubility study resulted in showing extremely low and variable concentration, ranging from 0.000063 to 0.00029 mg/L, in dilution water, the definitive study was carried out using saturated test solution with non-dissolved test item under semi-static regime of three times renewal per week by considering the stability of the test item concentration in test solution. The mean measured concentration of the test item resulted in 0.00077 mg/L which was around the solubility in dilution water obtained in water solubility study. While the measured concentrations of the test item before the renewal increased from that at the preparation, it might be caused by gradually dissolving the test item insoluble in the test solution into it, however, the cause of it was not obvious as the measured concentration of the test item varied remarkably. No effects on the parent animal and on the reproduction were obtained around the solubility of the test item in the dilution water. Consequently, these results suggest that the test item has no effect on daphnid reproduction and the NOEC on the reproduction is >0.00077 mg/L
The environmental conditions were within the suitable range, therefore, it is concluded that this study complied with the applied test guideline.
21-day EC50 (concentration causing 50 per cent reduction in reproduction) >0.00077mg/L
21-day LC50 for parent daphnid (median lethal concentration) >0.00077 mg/L
NOEC (no observed effect concentration) >0.00077 mg/L
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