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EC number: 456-990-3 | CAS number: 244761-29-3 LITHIUM-BIS(OXALATO)BORATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-12-17 to 2010-01-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline compliant study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- , adopted 17.07.92, Limit Test
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Test concentrations of Range-Finding Test: Control, 1 mg/L, 10 mg/L and 100 mg/L;
Test concentrations of Definite Test as Limit Test: Control, 100 mg/L
- Sampling method: In the Range-Finding Test pH-value, dissolved oxygen concentration and temperature were registered at start and end of test
periods
0 - 24 h and 24 - 48 h. In the Definite Test as Limit Test pH-value, dissolved oxygen concentration and temperature were registered at start and end of test periods 0 - 24 h, 24 - 48 h, 48 - 72 h and 72 - 96 h. Samples of the control and test concentration of 100 mg/L of the Definite Test as Limit Test were taken for AES-analysis (AES=Atomic Emission Spectroscopy) at the start and end of test periods 0 - 24 h and 72 - 96 h to assess stability of exposure
concentrations. - Vehicle:
- no
- Details on test solutions:
- The test item Lithium-bis(oxalato)borate was delivered on 02.11.09 and kept at room temperature until starting of the Range-Finding- and Definite Fish Test.
According to Safety Data Sheet of 29.10.09 the test item Lithium-bis(oxalato) borate has a purity of > 99.4 % and is a solid powder that solubilises in water
under hydrolysis. Information provided by the study sponsor Rockwood Lithium GmbH of 15.03.09 confirms, that hydrolysis products of Lithium-bis(oxalato)borate are Boric acid, Oxalic acid and Lithiumhydrogenoxalate. As these hydrolysis products lead to a decrease of the pH-value, a preliminary study in de-chlorinated tap water was accomplished, to assess the course of pH-values under test conditions.
For the Range-Finding Test the test concentrations of 1, 10 and 100 mg/L were prepared in 2 L glass beakers in de-chlorinated tap water by stirring for 1 minute at 8000 rpm using a mixing device (Ultra-Turrax, Janke & Kunkel).
For the Definite Test as Limit Test the test concentrations of 100 mg/L were prepared in a 20 L solid-glass fish tank in de-chlorinated tap water by stirring for 2 minutes at 8000 rpm using a mixing device (Ultra-Turrax, Janke & Kunkel).
For the Range-Finding Test the test solutions were prepared for test periods of
0 - 24 h and 24 - 48 h. For the Definite Test as Limit Test the test concentrations of 100 mg/L were prepared for test periods of 0 - 24 h, 24 - 48 h, 48 - 72 h
and 72 - 96 h. The test solutions were replenished after each successive 24-h exposure period (i.e. semi-static test) for a total exposure period of 48 h in the
Range-Finding Test and 96 h in the Definite Test as Limit Test. The test solutions obtained using this method were clear at first and became turbid within a few minutes. A whitish precipitation, obviously formed by Calciumoxalate and Calciumcarbonate, could be observed after each 24-h exposure period.
The Range-Finding- and Definite Fish Test were carried out without adjustment of the pH.
The fish were transferred into the test solutions immediately after preparation.
Samples for AES-analysis (AES=Atomic Emission Spectroscopy) including control media and test solutions of the Definite Test as Limit Test were taken at
the start and end of test periods 0 - 24 h and 72 - 96 h. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
Species: Zebra Fish (Danio rerio), Teleostei, Cyprinidae
Supplier: Max-Planck-Institut für Entwicklungsbiologie, Tübingen
Pre-treatment: none, the animals were kept in an air-conditioned room
(light/dark = 16 h/8 h; illumination: fluorescent tubes);
for > 12 days before testing, mortality < 1 %
(nominal value ≤ 5 %)
Size: 3.0 - 3.5 cm - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- Total hardness: 8,97 °dH
Carbonate hardness: 6,98 °dH, - Test temperature:
- 23 ± 2°C (test water)
- pH:
- pH-values of control: in a range of 8.0 - 8.1
pH-values of Definite Test concentration 100 mg/L: in a range of 7.2 - 7.6 - Dissolved oxygen:
- Dissolved oxygen of control: in a range of 94 - 99 %
Dissolved oxygen of of Definite Test concentration 100 mg/L: in a range of 94 - 98 % - Nominal and measured concentrations:
- Results of AES-analysis confirmed stability of the test solutions in a range of 99.7 % to 103.6 %. The values corresponded with the expected
concentration of Lithium, calculated from the loading of 100 mg/L of the test item Lithium-bis(oxalato)borate and the amount of Lithium in the
test item
(3.58 % theoretical value, calculated from the sum formula). As a consequence results of the Definite
Fish Test were referred to the nominal concentrations. - Details on test conditions:
- TEST CONDITIONS
Range-Finding Test:
Loading: 2 animals/test concentration
Duration: 48 h
Test vessels: 2 L glass beakers
Test volume: 1.5 L
Mode: semi-static
Water renewal: every 24 h
Temperature: 23 ± 2°C (test water)
Light: fluorescent tubes (16 h light, 8 h dark)
Aeration: none
Feeding: no feeding during the test
Water: de-chlorinated tap water
Total hardness: 8,97 °dH
Carbonate hardness: 6,98 °dH,
Nitrate: 4,4 mg/L, Nitrite: < 0,005 mg/L,
Ammonium: < 0,01 mg/L, Hg/Cd/Pb/Cu/Ni: < 0,001 mg/L
Definite Test:
Loading: 7 animals/test concentration
Duration: 96 h
Test vessels: 20 L solid-glass fish tanks
Test volume: 7 L
Mode: semi-static
Water renewal: every 24 h
Temperature: 23 ± 2°C (test water)
Light: fluorescent tubes (16 h light, 8 h dark)
Aeration: none
Feeding: no feeding during the test
Water: de-chlorinated tap water (see above) - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Validity criteria fulfilled:
- yes
- Conclusions:
- Test solutions of Lithium bis(oxalato)borate caused no acute toxic effects on Danio rerio. A 96-h LC50 of > 100 mg/L and a NOEC of 100 mg/L have been determined.
- Executive summary:
Lithium bis(oxalato)borate was assessed in a short term toxicity study to fish according to OECD guideline 203. Lithium-bis(oxalato)borate caused no acute toxic effects on Danio rerio. A 96-h LC50 of > 100 mg/L and a NOEC of 100 mg/L have been determined.
Reference
Description of key information
LiBOB was tested for acute toxicity to freshwater fish in a 96h-semi-static test. The test item showed no mortality up to a nominal concentration of 150 mg/L revealing a LC50 of greater than 150 mg/L and a NOEC of 150 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 150 mg/L
Additional information
LiBOB was assessed in a short-term toxicity to fish study, according to OECD guideline 203 and EU method C.1. Young zebrafish were exposed to the test item in a semi-static test for 96 h at nominal concentrations of 0, 100 and 150 mg/L. The test item showed no mortality up to a nominal concentration of 150 mg/L. Therefore the 96 h LC 50 was determined to be greater than 150 mg/L and the 96 h NOEC was determined to be 150 mg/L. (MEP, 2011)
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