Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
other: not specified
Title:
Chronic Toxicity Summary Isophorone
Author:
not specified

Materials and methods

Study type:
other: not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5,5-trimethylcyclohex-2-enone
EC Number:
201-126-0
EC Name:
3,5,5-trimethylcyclohex-2-enone
Cas Number:
78-59-1
Molecular formula:
C9H14O
IUPAC Name:
3,5,5-trimethylcyclohex-2-enone

Method

Type of population:
occupational
Ethical approval:
not specified

Results and discussion

Results:
Workers exposed to 5-8 ppm (28-45 mg/m³) of the test substance for one month complained of fatigue and malaise. When concentrations were reduced to 1-4 ppm, no adverse effects were reported.

Applicant's summary and conclusion