Registration Dossier
Registration Dossier
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EC number: 203-419-9 | CAS number: 106-65-0
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Dicarboxylic acid (C4–C6) dimethylester, mixture (dimethyl succinate, dimethyl adipate, dimethyl glutarate and their mixture)
- Year:
- 2 007
- Bibliographic source:
- The MAK-Collection for Occupational Health and Safety
Materials and methods
Test material
- Reference substance name:
- Dimethyl succinate
- EC Number:
- 203-419-9
- EC Name:
- Dimethyl succinate
- Cas Number:
- 106-65-0
- Molecular formula:
- C6H10O4
- IUPAC Name:
- dimethyl succinate
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 90 days exposure
Doses / concentrations
- Dose / conc.:
- 400 mg/m³ air
Results and discussion
Any other information on results incl. tables
No adverse, substance-related effects on the reproductive organs were observed. Changes in individual hormone parameters and increased epididymal sperm counts were evaluated by the authors as unclear or as not assignable due to the high variability of the data and the relatively low number of animals/group and sex.
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, no adverse substance-related effects on the reproductive organs were observed.
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