1-(3,5-Dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

20 Pa

Remarks on result:

other: Saturator column flow rate of 30 mL/min

Test no.:

#2

Temp.:

20 °C

Vapour pressure:

20 Pa

Remarks on result:

other: Saturator column flow rate of 40 mL/min

Test no.:

#3

Temp.:

20 °C

Vapour pressure:

20 Pa

Remarks on result:

other: Saturator column flow rate of 50 mL/min

Test no.:

#4

Temp.:

25 °C

Vapour pressure:

30 Pa

Remarks on result:

other: Saturator column flow rate of 30 mL/min

Test no.:

#5

Temp.:

25 °C

Vapour pressure:

30 Pa

Remarks on result:

other: Saturator column flow rate of 40 mL/min

Test no.:

#6

Temp.:

25 °C

Vapour pressure:

30 Pa

Remarks on result:

other: Saturator column flow rate of 50 mL/min

Table 1: mass of test substance condensed

Temperature [°C]	Saturator column flow rate [mL/min]	Concentration of sample solution [µg]	Mass of test substance vaporised [µg]	Total mass of test substance vaporised [µg]
20	30 – trap 1	153	6.11 x 10^3	6.11 x 10^3
	30 – trap 2	not detected	none
	40 – trap 1	202	8.08 x 10^3	8.08 x 10^3
	40 – trap 2	not detected	none
	50 – trap 1	260	1.04 x 10^4	1.04 x 10^4
	50 – trap 2	not detected	none
25	30 – trap 1	222	8.87 x 10^3	8.87 x 10^3
	30 – trap 2	not detected	none
	40 – trap 1	301	1.20 x 10^4	1.20 x 10^4
	40 – trap 2	not detected	none
	50 – trap 1	391	1.56 x 10^4	1.56 x 10^4
	50 – trap 2	not detected	none

Table 2: experimental vapour pressure values

Temperature [°C]	Saturator column flow rate [mL/min]	Total volume of gas [mL]	Mass of test item vaporised [µg]	Vapour pressure [Pa]	Mean vapour pressure [Pa]
20	30	2.8 x 10^3	6.11 x 10^3	20	20
	40	3.71 x 10^3	8.08 x 10^3	20
	50	4.77 x 10^3	1.04 x 10^4	20
25	30	2.91 x 10^3	8.87 x 10^3	30	30
	40	1.20 x 10^4	1.20 x 10^4	30
	50	1.56 x 10^4	1.56 x 10^4	30

Conclusions:

The vapour pressure of the substance was determined to be 20 Pa at 20 °C and 30 Pa at 25 °C.

Executive summary:

The vapour pressure of the substance was determined under GLP in accordance with OECD TG 104 applying the gas saturation method. Glass beads (2 mm diameter, 20 g per aliquot of 200 mg test substance) were treated with test substance and then filled into saturator columns plugged with glass wool. The columns were then connected to a nitrogen supply and a stream of nitrogen at nominal flow rates of 30, 40 and 40 mL/minute was passed through the columns. The saturator columns were encased in glass jackets containing water that was maintained at the test temperatur using a thermostatically controlled circulating waterbath. Two condensation tubes, cooled in a bath at about -20 °C were connected in series to the outlet of each saturator columns. Testing was conducted at 20 and 25 °C, using a gas flow time of 90 minutes before assessing the mass of test item vaporised over this time period. After the completion of the test, the condensation tubes were disconnected from the columns and quantitatively rinsed with acetonitrile. The amount of transferred test substance in each of the tubes was determined analytically with gas chromatography. The vapour pressure was determined to be 20 Pa at 20 °C and 30 Pa at 25 °C.

Description of key information

Vapour pressure = 20 Pa at 20 °C, 30 Pa at 25 °C (OECD TG 104, GLP)

Key value for chemical safety assessment

Vapour pressure:

20 Pa

at the temperature of:

20 °C