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EC number: 217-639-8 | CAS number: 1918-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 11 December 1981 to 12 February 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- number of dose levels
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-thienylacetic acid
- EC Number:
- 217-639-8
- EC Name:
- 2-thienylacetic acid
- Cas Number:
- 1918-77-0
- Molecular formula:
- C6H6O2S
- IUPAC Name:
- 2-(thiophen-2-yl)acetic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA-CREDO, 69210 Saint Germain sur l'Arbresle
- Females (if applicable) nulliparous and non-pregnant: no data
- Age at study initiation: no data
- Weight at study initiation: 115 g (mean, males), 115 g (mean, females)
- Fasting period before study: yes
- Housing: polycarbonate cages, 40.8x33.3x15 cm
- Diet: diet 890 (Nafag, Swiss)
- Water: ad libitum
- Acclimation period: at least 4 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20-25°C
- Humidity (%): 50% ± 20%
- Air changes: 10-11 per hour
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 17.12.1981 To: /
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 100-500 mg/mL
- Amount of vehicle: 10 mL/kg
- Justification for choice of vehicle: no data
- Lot/batch no.: 58.C015.6 (Prolabo, Paris)
- Purity:
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg - Doses:
- 5000, 2500, 2000 and 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality (observed daily but reported at 1h, 4h, D1, D4, D7 and D14), clinical signs (regularly), body weight (D0, D4, D7 and D14)
- Necropsy of survivors performed: yes - Statistics:
- The LD50 is determined with the Litchfield & Wilcoxon method.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 260 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 548 - <= 3 300
- Mortality:
- No mortality is observed at 1000 mg/kg bw.
At 2000, 2500 and 5000 mg/kg bw, mortality is increased with the dose level. See table. - Clinical signs:
- other: sedation (dose-dependent) during 20-48 hours at 2000, 2500 and 5000 mg/kg bw. No effect observed thereafter.
- Gross pathology:
- no effect, except stomacal erosion in one animal at 2000 mg/kg bw.
Any other information on results incl. tables
Mortality:
dosis | cumulated mortality | ||||||
(mg/kg) | 1h | 4h | D1 | D4 | D7 | D14 | total % |
1000 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2000 | 0 | 0 | 3 | 4 | 4 | 4 | 40 |
2500 | 0 | 0 | 2 | 6 | 6 | 6 | 60 |
5000 | 1 | 5 | 9 | 9 | 9 | 9 | 90 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- In this study in rats the oral LD50 is 2260 mg/kg bw (male/female, gavage)
- Executive summary:
In an acute oral toxicity study, groups of fasted Wistar rats (5/sex/dose level) were given a single oral dose of 2-Thienylacetic acid in CMC at doses of 1000, 2000, 2500 and 5000 mg/kg bw and observed for 14 days.
Oral LD50 Combined = 2260 mg/kg bw (95% C.I.: 1548-3300)
Based on this LD50, 2-Thienylacetic acid is classified in Category 5 of GHS, but not classified according to the CLP criteria.
Major treatment related clinical sign is sedation. No effect were observed on body weight or at necropsy (except stomacal erosion in one animal at 2000 mg/kg bw).
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