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EC number: 500-046-6 | CAS number: 26183-52-8 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (OECD 401), rat: LD50 > 2000 mg/kg bw
Dermal (OECD 402), rabbit: LD50 > 2000 mg/kg bw
Inhalation (OECD 403), rat, 4 h, (limit test): LC50 > 1600 mg/m³
(maximum technically attainable concentration)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the category justification provided in IUCLID Section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Effect level:
- > 5 050 mg/kg bw
- Remarks on result:
- other: Source: CAS 68002-97-1, Sasol, 1992a
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Conclusions:
- A LD50 of > 5050 mg/kg bw was determinied for male and female rats.
- Executive summary:
The acute oral toxicity of the target substance is estimated based on an adequate and reliable in vivo study of a structural analogue source substances. A LD50 value of > 5050 mg/kg bw has been determined for male and female rats. Therefore, a LD50 value of > 2000 mg/kg bw for the target substance is considered for the hazard assessment and C&L purposes. As explained in the category justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the acute oral toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable (Klimisch score 1) study from a source substance with similar structures and intrinsic properties. Read-across is justified based on a common metabolic breakdown of target and source substances and consistent trends in environmental fate, ecotoxicological and toxicological properties. The selected study is thus sufficient to fulfil the standard information requirements set out in Annex VII, Item 8.5, in accordance with Annex XI, Item 1.5, of Regulation (EC) No. 1907/2006.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Refer to the category justification provided in IUCLID Section 13
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 600 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Source, WoE, 68002-97-1, 1982a
- Remarks:
- Maximum attainable concentration.
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: Source, WoE, 112-59-4, 1987
- Remarks:
- Effect level represents calculated saturated vapour pressure.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- The inhalation LD50 values determined range from > 100 mg/m3 air to > 1600 mg/m3 air for male and female rats. The values represent the maximum attainable concentration and the calculated saturated vapour pressure of the test materials, respectively.
- Executive summary:
The acute inhalation toxicity of the target substance is estimated based on two adequate and reliable in vivo studies of structural analogue source substances. The inhalation LD50 values determined range from > 100 mg/m3air to > 1600 mg/m3air for male and female rats. The values represent the maximum attainable concentration and the calculated saturated vapour pressure of the test materials, respectively. Therefore, no hazard for the target substance is identified and C&L is set accordingly. As explained in the category justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the acute inhalation toxicity
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- As described in guideline.
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Concentrations:
- Saturated vapour atmosphere (calculated)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: Effect level represents calculated saturated vapour pressure.
- Mortality:
- No treatment-related effects.
- Clinical signs:
- other: No treatment-related effects.
- Body weight:
- No treatment-related effects.
- Gross pathology:
- No treatment-related effects.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- As described in guideline.
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- TEST ATMOSPHERE
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 1.90 ± 1.82 - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 1.60 mg/L air, corresponding to 1600 mg/m3
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1.6 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Maximum attainable concentration.
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 600 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Maximum attainable concentration.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: Slight nasal discharge and lacrimation during exposure as well as slight, red nasal discharge postexposure.
- Body weight:
- Slight reduction in the mean body weight gain was noted in females on Day 14 postexposure.
- Gross pathology:
- The following gross pathology was noted at the terminal sacrifice: one male had dilated, fluid filled left renal pelvis; one male and one female had enlarged mandibular lymph nodes; another female had dilated right renal pelvis containing firm, granular, white material and uterine horns distended with clear fluid; and one female had a dilated right renal pelvis containing white granular fluid. Three of five males and two of five females had no observable abnormal lesions at the terminal sacrifice.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 1 600 mg/m³
- Quality of whole database:
- The available information comprises adequate and reliable (Klimisch score 2) studies from various source substances with similar structures and intrinsic properties. Read-across is justified based on a common metabolic breakdown of target and source substances and consistent trends in environmental fate, ecotoxicological and toxicological properties. The selected studies are thus sufficient to fulfil the standard information requirements set out in Annex VIII, Item 8.5, in accordance with Annex XI, Item 1.5, of Regulation (EC) No. 1907/2006.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Refer to the category justification provided in IUCLID Section 13
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Source, WoE, 68002-97-1, 1982b
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Source, WoE, 68439-50-9 (3EO), 1990a
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Source, WoE, 66455-14-9, 1979
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Source, WoE, 68131-39-5, 1978
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- Individual LD50 values determined in male and female rabbits range from > 2000 mg/kg bw to > 3000 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the target substance is estimated based on adequate and reliable in vivo studies of structural analogue source substances. Individual LD50 values determined range from > 2000 mg/kg bw to > 3000 mg/kg bw for male and female rabbits. Therefore, a LD50 value of > 2000 mg/kg bw for the target substance is considered for the hazard assessment and C&L purposes. As explained in the category justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the acute dermal toxicity.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- According to Guideline.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 1000, 2000, 4000 mg/kg bw
- No. of animals per sex per dose:
- 4
- Control animals:
- not required
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Abraded skin.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- As described in guideline.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occurred.
- Clinical signs:
- No data about systemic toxicity.
- Body weight:
- No data.
- Gross pathology:
- No data.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Only 4 animals per sex
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- As described in guideline.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 4
- Control animals:
- not required
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 10 instead of 5 animals used, Occlusive conditions, Limit dose was 3000 instead of 2000 mg/kg bw
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hare-Marland, New Jersey, USA
- Housing: Individually
- Weight at study initiation: 2 to 3 kg
- Diet (ad libitum): Purina Rabbit Ration
- Water (ad libitum): Tap water
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3
- Humidity (%): 30 to 70
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: Animals were wrapped with rubber dam and an elastic bandage to retard evaporation.
REMOVAL OF TEST SUBSTANCE
The test site was not rinsed after removal of the patch. - Duration of exposure:
- 24 h
- Doses:
- 3000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were recorded daily through Day 14. Body weights were recorded at initiation and on Days 7 and 14.
- Necropsy of survivors performed: yes - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed.
- Mortality:
- No mortalities occured.
- Clinical signs:
- Clinical signs observed during the Limit Test included poor grooming (observed from Day 2 to 5 in all animals), decreased muscle tone (observed from Day 6 to 8 in maximum 2 males and 3 females) and dyspnea (observed from Day 3 to 10 in maximum 3 animals of each sex).
- Body weight:
- Mean body weights of day 7 were decreased compared to Day 1 but recoverd by Day 14.
- Gross pathology:
- Terminal necropsy revealed mottled and pale lung in one female and multiple cysts in the ovaries of two females.
- Other findings:
- Slight to severe erythema and edema and green discoloration of fur surrounding application site were observed. Necrosis, fissuring, and sloughing of the skin at application site was also observed.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The available information comprises adequate and reliable (Klimisch score 1 and 2) studies from various source substances with similar structures and intrinsic properties. Read-across is justified based on a common metabolic breakdown of target and source substances and consistent trends in environmental fate, ecotoxicological and toxicological properties. The selected studies are thus sufficient to fulfil the standard information requirements set out in Annex VIII, Item 8.5, in accordance with Annex XI, Item 1.5, of Regulation (EC) No. 1907/2006.
Additional information
To cover the endpoint acute toxicity of decan-1-ol, ethoxylated (1 -2.5 EO) (CAS 26183-52-8), studies from similar substances were taken for read-across of key information or in a Weight-of-Evidence approach. Read-across is justified because the length of the alkyl chain does not exert any meaningful influence on acute toxicity, whereas the degree of ethoxylation is of more importance. Up to the level of EO = 4, which includes all read-across substances, the toxicity is low (HERA, 2009).
Acute oral toxicity
The study addressing acute oral toxicity with C10-16AE (CAS 68002-97-1) was conducted according to OECD Guideline 401 (Sasol, 1992a). In this limit test five Sprague-Dawley rats per sex received 5050 mg/kg bw. No mortalities occurred, resulting in a LD50 value of greater than 5050 mg/kg bw. Clinical signs comprised activity decrease, diarrhoea, piloerection and polyuria. Moreover, necropsy revealed no effects.
Acute inhalation toxicity
There are two studies available addressing acute inhalation toxicity, being performed with C6-10AE (CAS 112-59-4) and C10-16AE (CAS 68002-97-1) and equivalent to OECD Guideline 403.
In the first study five Wistar rats per sex were exposed for a period of 6 h to a vapour of C6-10AE (EO2, CAS 112-59-4) at the calculated saturated vapour concentration of 100 mg/m³ (Ballantyne, 1987). No mortality or clinical signs occurred during the exposure period. The LC50 was determined to be greater than 100 mg/m³ for exposure to an aerosol of the test substance for 6 h.
In the second study with C10-16AE (EO2, CAS 68002-97-1) five Sprague Dawley rats/sex were exposed for a period of 4 h to an aerosol of the test substance at a concentration of 1600 mg/m³ (corresponding to 1.6 mg/L), which is the maximum technically attainable concentration of the test substance with a MMAD < 4 µm (Sasol, 1982a). No mortality occurred during the exposure or the 14-day observation period. The animals demonstrated clinical signs of toxicity like slight nasal discharge and lacrimation during exposure as well as slight, red nasal discharge post-exposure. The LC50 was determined to be greater than 1600 mg/m³ for exposure to an aerosol of the test substance for 4 h.
Acute dermal toxicity
The study with C10-16AE (EO2, CAS 68002-97-1) was conducted equivalent to OECD Guideline 402 (Sasol, 1982b) as limit test. In this study, five New Zealand White rabbits per sex were treated with 2000 mg/kg bw for 24 h under occlusive conditions. No mortalities occurred, hence, the LD50 value was greater than 2000 mg/kg bw.
With C12-13AE (EO2, CAS 66455-14-9), a study according to OECD Guideline 402 was carried out on four Wistar rats per sex and dose (Shell, 1979). Both sexes were dosed at 1000, 2000 and 4000 mg/kg bw under occlusive conditions for 24 h. Mortalities occurred at a dose level of 2000 mg/kg bw and above, resulting in a LD50 of greater than 2000 mg/kg bw.
The study conducted with C12-14AE (EO3, CAS 68439-50-9) was performed as limit test similar to OECD Guideline 402 (Huntsman, 1990a). In this limit test five New Zealand White rabbits per sex were treated with 3000 mg/kg bw for 24 h under occlusive conditions. No mortalities occurred, hence, the LD50 value was set to greater than 3000 mg/kg bw.
In the last study regarding acute dermal toxicity, a limit test with C12-15AE (EO3, CAS 68131-39-5) was conducted equivalent to OECD Guideline 402 (Shell, 1978). Four Wistar rats per sex were treated with 2000 mg/kg bw for 24 h under occlusive conditions. No treatment-related clinical signs or mortalities were observed. Hence, the LD50 was greater than 2000 mg/kg bw.
Justification for classification or non-classification
According to the classification criteria of Regulation (EC) No. 1272/2008 the substance does not need to be classified for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.