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EC number: 220-638-5 | CAS number: 2842-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(N-methyl-p-toluidino)ethanol
- EC Number:
- 220-638-5
- EC Name:
- 2-(N-methyl-p-toluidino)ethanol
- Cas Number:
- 2842-44-6
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 2-[methyl(4-methylphenyl)amino]ethan-1-ol
- Test material form:
- liquid: viscous
Constituent 1
- Specific details on test material used for the study:
- Firstcure MHPT, was received September 22th, 1999. The test substance was a tan semi-solid and was stored at room temperature (approxitnately 22 °C). All chemical analyses and documentation pertaining to the characterization (i.e., stability and purity) of the bulk test substance were the responsibility of the Sponsor. The Sponsor's Material Safety Data Sheet indicated that the test substance was stable.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female Sprague-Dawley rats (Crl:CD RBR), approxitnately 7.5 weeks of age, were purchased from Charles River Laboratories, Kingston, NY, for use in this study. The animals were received on October 20, 1999 and a randorn sample (25%) of the shippient weighed 162-197 g the next day. The rats were held in quarantine for two weeks during which time they were observed daily for survival. At the end of the quarantine period, the rats were examined carefully to ensure their health and suitability as test subjects. Rats selected for the study were identified by a uniquely numbered metal tag inserted through the pinna of the right ear and by a cage card bearing the corresponding identification number.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male rat died during the study (Day 3).Mortality incidences are summarized in Table 1. One male rat died during the study (Day 3).
- Clinical signs:
- other: Clinical signs observed during the study included hypoactivity, redness around eyes, lacrimation, salivation, discoloration around mouth, redness around nose fur, discoloration,inguinal fur, rales and discolored paws. All surviving animals appeared day 5
- Gross pathology:
- Dark red adrenal glands were observed in the male rat that gross lesions were observed in any surviving rat at at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study, the acute oral median lethal dose (LD50) of MHPT in male and female rats was greater than 2 g/kg of body weight.
- Executive summary:
MHPT was administered as a 20% (w/v) solution in corn oil by oral gavage to one group of five male and five female Sprague-Dawley rats in a single dose of 2 g/kg of body weight. Rats were observed for 14 days after test substance administration. One male rat died during the study (Day 3). Clinical signs observed during the study included hypoactivity, redness around eyes, lacrimation, salivation, discoleration around mouth, redness around nose fur, discolored inguinal fur, rales and discolored paws. All surviving animals appeared normal by Day 5 and remained so for the duration of the study. All surviving rats gained weight during the study and no gross lesions were observed inatry of these rats at necropsy. Dark red adrenal glands were observed from the one male rat that died. Based on the results of this study, the acute oral median lethal dose (LD50) of MHPT in male and female rats was greater than 2 g/kg of body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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