4-pentylcyclohexanone

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1990-08-15 to 1990-12-13

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

2 Pa

Test no.:

#2

Temp.:

50 °C

Vapour pressure:

22 Pa

Test no.:

#3

Temp.:

100 °C

Vapour pressure:

503 Pa

(a) Summary

 

The vapour pressure at 20 °C was calculated to be 2 Pa.

The vapour pressure at 50 °C was calculated to be 22 Pa.

The vapour pressure at 100 °C was calculated to be 503 Pa.

 

(b) presentation of the results including calculation and statistical methods 

Vapour pressure at 20 °C (293 K) 

1. measurement:         2.7 Pa

2. measurement:         1.2 Pa

3. measurement:          2.5 Pa 

Mean:                        2.13 Pa ± 0.81 Pa

 

Vapour pressure at 50 °C (323 K) 

1. measurement:         28 Pa

2. measurement:         13 Pa

3. measurement:          25 Pa 

Mean:                        22.0 Pa ± 7.9 Pa

 

Vapour pressure at 100 °C (373 K) 

1. measurement:         609 Pa

2. measurement:         356 Pa

3. measurement:          544 Pa 

Mean:                        503.0 Pa ± 131.4 Pa

 

The relative standard deviation of the results was 38 % (at 293 K), 36 % (at 323 K) and 26 % (at 373 K). The standard deviations were greater than the repeatability of the method given in the EEC Directive. There are two explanations for this; 1. The vapour pressure of the substance was so high that determination with the vapour pressure balance was barely possible. A determination at the limit of the method naturally had a higher standard deviation. Two of the three repeat measurements were close together but the third deviates by a factor of about 2. The database is too small to eliminate this value as an outlier.

Conclusions:

The vapour pressure at 20 °C was determined to be 2 Pa and at 50 °C to be 22 Pa respectively.

Executive summary:

A study was conducted according to, Regulation (EC) No 440/2008 method A.4 ato determine the vapour pressure of the test item. The vapour pressure of the test item was determined at three different temperatures (20, 50 and 100 °C) using the effusion method (weight loss). The relative standard deviation of the results is 38 % (at 293 K), 36 % (at 323 K) and 26 % (at 373 K). The standard deviations are greater than the repeatability of the method given in the EEC Directive. The vapour pressure of the substance was near to the upper limit of the method. Thus, the determination with the vapour pressure balance barely possible. A determination at the limit of the method naturally had a higher standard deviation. Two of the three repeat measurements were close together but the third deviates by a factor of about 2. The vapour pressure at 20 °C was determined to be 2 Pa and at 50 °C to be 22 Pa respectively.

Description of key information

The vapour pressure at 20 °C was determined to be 2 Pa and at 50 °C to be 22 Pa respectively (reference 4.6 -1).

Key value for chemical safety assessment

Vapour pressure:

2 Pa

at the temperature of:

20 °C

Additional information

A study was conducted according to, Regulation (EC) No 440/2008 method A.4 ato determine the vapour pressure of the test item (reference 4.6 -1). The vapour pressure of the test item was determined at three different temperatures (20, 50 and 100 °C) using the effusion method (weight loss). The relative standard deviation of the results is 38 % (at 293 K), 36 % (at 323 K) and 26 % (at 373 K). The standard deviations are greater than the repeatability of the method given in the EEC Directive. The vapour pressure of the substance was near to the upper limit of the method. Thus, the determination with the vapour pressure balance barely possible. A determination at the limit of the method naturally had a higher standard deviation. Two of the three repeat measurements were close together but the third deviates by a factor of about 2. The vapour pressure at 20 °C was determined to be 2 Pa and at 50 °C to be 22 Pa respectively.