Registration Dossier
Registration Dossier
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EC number: 204-612-0 | CAS number: 123-25-1
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 = 8530 mg/kg bw
Acute dermal toxicity: LD50 >= 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No more details available, database match.
- GLP compliance:
- not specified
- Species:
- rat
- Route of administration:
- oral: unspecified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 8 530 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral median lethal dose (LD50) in the rat is reported as being 8530 mg/kg bw.
- Executive summary:
The oral median lethal dose (LD50) in the rat is reported as being 8530 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 8 530 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No more details available, database match.
- GLP compliance:
- not specified
- Species:
- rabbit
- Sex:
- not specified
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 5 000 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Median lethal dose (LD50) in the rabbit following demal administration is reported to be in excess of 5000 mg/kg bw.
- Executive summary:
Median lethal dose (LD50) in the rabbit following demal administration is reported to be in excess of 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Additional information
Justification for classification or non-classification
Based on the results of the available data the substance does not require to be classified and labelled according to Regulation 1272/2008/EC (CLP) or Directive 67/548/EEC (DSD).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
