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Diss Factsheets
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EC number: 700-697-8 | CAS number: 264145-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 24 January to 09 February 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- LumiNova G and LumiNova BG are both inorganic substances comprising of > 99% aluminium strontium oxide but in slightly different proportions, they are both doped with dysprosium and europium and have negligible impurities. They are therefore considered to be very similar in physical and chemical characteristics and suitable for using in a one-to-one scenario.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Luminova
- IUPAC Name:
- Luminova
- Details on test material:
- - Name of test material (as cited in study report): LumiNova
- Substance type: Luminous
- Physical state: Powder
- Analytical purity: 100% w/w
- Lot/batch No.: NR-003-1
- Expiration date of the lot/batch: May 1996
- Stability under test conditions:
- Storage condition of test material: In the dark at room temperature in dry conditions.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Laboratory animal supplier
- Age at study initiation: 4 to 7 weeks
- Weight at study initiation: 111 to 125 g
- Fasting period before study: Access to food only was prevented overnight prior to and approximately 4 hours after dosing.
- Housing: Metal cages with wire mesh floors
- Diet: Biosure LAD 1, ad libitum
- Water: ad libitum
- Acclimation period: 13 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 30 - 70% R.H.
- Air changes (per hr): 10 to 15
- Photoperiod: 12 hr of artifical light, 0700 - 1900h
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% w/v
- Amount of vehicle (if gavage): 10 ml/kg bw
- Justification for choice of vehicle:
- Lot/batch no. (if required):
- Purity:
MAXIMUM DOSE VOLUME APPLIED:
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - No. of animals per sex per dose:
- Preliminary sighting study: 1 (female)
Main study: 5 (male)
Main study: 5 (female) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: At least twice daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
- Preliminary study:
- LumiNova G and LumiNova BG are both inorganic substances comprising of > 99% aluminium strontium oxide but in slightly different proportions, they are both doped with dysprosium and europium and have negligible impurities. They are therefore considered to be very similar in physical and chemical characteristics and suitable for using in a one-to-one scenario.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No. with evident toxicity: ; No. of deaths: 0; No. of animals used: 5
- Mortality:
- None
- Clinical signs:
- other: Signs of toxicity: Piloerection was observed in all rats within five minutes of dosing and was persistent in all animals throughout Day 1 and Day 2. Recovery of all rats, as judged by external appearance and behaviour, was complete by the morning of D
- Gross pathology:
- Effects on organs:
Terminal autopsy findings were normal.
Any other information on results incl. tables
Study |
Result for LumiNova BG (Target chemical) |
Result for LumiNova G (Source chemical) |
Notes |
Physical appearance |
Inorganic light yellowish green powder |
Inorganic phosphorescent yellow powder |
|
Melting point |
Waived |
Waived |
In accordance with Column 2 adaptation statement of REACH Annex VII, Information requirement section 7.2, this study does not need to be conducted below a lower limit of -20°C. |
Boiling point |
Waived |
Waived |
The study is not needed for solids which melt above 300°C or decompose before boiling and has been omitted in accordance with Column 2 of Annex VII Section 7.3 of the REACH regulation. |
Density |
RD = 3.6 |
RD = 3.63 |
|
Particle size |
25.9% =< 10.4µm 74.1% =< 30µm |
3.51% <= 2.00 µm
|
|
Vapour pressure |
Waived |
Waived |
In accordance with Column 2 adaptation statement of REACH Annex VII, information requirement section 7.5, this study does not need to be conducted if the melting point is >300°C |
Partition coefficient |
0 |
< 0 at 20°C |
Read-across |
Water solubility |
88.0 mg/l |
300 mg/l at 20°C |
|
Surface tension |
72 mN/m |
69.9 mN/m |
|
Flash point |
Waived |
Waived |
Flash point is a property relevant to liquids and low melting point solids and so is waived in accordance with Section 2 of annex XI of the REACH regulation. |
Auto flammability |
Waived |
Waived |
Undertaking this study is unjustified because the test substance is inorganic with a melting point > 1300°C. |
Flammability |
Waived |
Waived |
Undertaking this study is unjustified because the test substance is inorganic with a melting point > 1300°C. |
Explosiveness |
Waived |
Waived |
In accordance with Column 2 adaptation statement of REACH Annex VII, information requirement section 7.11, this study does not need to be conducted based on a structural assessment of the substance. Examination of the structure indicates that there are no groups associated with explosive properties. |
Oxidising properties |
Not oxidising |
Not oxidising |
|
Biodegradation in water |
Waived |
Waived |
In accordance with column 2 of REACH annex VII, this study does not need to be conducted if the substance is inorganic. |
Acute toxicity to Daphnia |
48h EC50 = 13mg/l |
48h EC50 = 13 mg/l |
Read-across |
Acute toxicity to algae |
72h EC50 = 29 mg/l |
72h EC50 = 29 mg/l |
Read-across |
Acute oral toxicity |
Discriminating dose > 2000 mg/kg bw |
Discriminating dose > 2000 mg/kg bw |
Read-across |
Skin irritation |
Not irritating |
Not irritating |
|
Eye irritation |
Not irritating |
Not irritating |
|
Skin sensitisation |
Not sensitising |
Not sensitising |
Read-across |
Genetic toxicity - Ames |
Not mutagenic |
Not mutagenic |
|
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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