Registration Dossier
Registration Dossier
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EC number: 246-885-9 | CAS number: 25354-97-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A QSAR model, ECOSAR was used to estimate short-term toxicity to fish.
- Justification for type of information:
- QSAR prediction from reliable model
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program was used to estimate the short-term toxicity to fish. The following measured values were used in the model: log Kow = 6.21, water solubility = 0.07 mg/L and melting point = -9 C.
- GLP compliance:
- no
- Analytical monitoring:
- not required
- Test organisms (species):
- other: fish
- Water media type:
- freshwater
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.35 mg/L
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Using a reliable QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program was used to estimate the 96hr LC50 for fish to be 0.35 mg/L.
- Executive summary:
A reliable QSAR model (Ecological Structure-Activity Relationship (ECOSAR) version 2.0) was used to predict the acute aquatic toxicity of 2-hexyldecanoic acid to fish. The 96 hour LC50 was 0.35 mg/L for the neutral organic class. This result will be used as key for short-term toxicity to fish.
Reference
Description of key information
An experimental acute fish toxicity test with 2 -hexyldecanoic acid is not available. However, a reliable calculated value from ECOSAR 2.0 is available.
A fish 96 hour LC50 of 0.35 mg/L was calculated for the substance.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 0.35 mg/L
Additional information
A fish 96 h LC50 of 0.35 mg/L was calculated for 2-hexyldecanoic acid using the ECOSAR 2.0 model.
An additional study result is available for the linear C16 acid. In that study no toxicity was observed at the level of water solubility.
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