Registration Dossier
Registration Dossier
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EC number: 701-289-2 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No genetic toxicity tests have been conducted with Reaction mass of aluminium and magnesium oxide and spinel (Mg(AlO2)2). A large database on genotoxic studies exists for soluble Al compounds. These studies indicate that Al(III) ions have clastogenic effects in vitro and in vivo. However, these findings are of little relevance for the elemental Al or aluminium skimmings because of the very low bioavailability of Al in its metallic form.
The other components of aluminium skimmings, Mg and ammonium are not toxicologically relevance because of their physiological abundance in the human body. The human dietary Al intake is around 10 mg/day in European male adults. This appreciable background exposure rules out a relevant mutagenicity of Al in vivo.
Reaction mass of aluminium and magnesium oxide and spinel (Mg(AlO2)2) are very poorly soluble in water (see Section 4.8). If in-vitro genotoxicity studies were conducted with Reaction mass of aluminium and magnesium oxide and spinel (Mg(AlO2)2), precipitation is going to occur at very low nominal test concentrations. On these grounds, it is very likely that these tests would produce a negative result.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
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