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EC number: 258-847-9 | CAS number: 53894-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The dermal acute toxicity test includes regular examination of rabbit skin following a single exposure over 14 days. The scoring of skin irritation was performed using the Draize scale. The exposure was conducted on abraded skin under occulsive conditions for 24 hours, a more extreme exposure than current guidelines. As a result the study provides information sufficient to address the skin irritation potential of the test substance.
- GLP compliance:
- no
- Remarks:
- Study precedes the development of Good Laboratory Practices
Test material
- Reference substance name:
- Triisononyl benzene-1,2,4-tricarboxylate
- EC Number:
- 258-847-9
- EC Name:
- Triisononyl benzene-1,2,4-tricarboxylate
- Cas Number:
- 53894-23-8
- Molecular formula:
- C36H60O6
- IUPAC Name:
- 1,2,4-tris(7-methyloctyl) benzene-1,2,4-tricarboxylate
- Test material form:
- liquid
- Details on test material:
- Production sample
Constituent 1
- Specific details on test material used for the study:
- Described as a clear yellow, slightly viscous liquid with a faint odor
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Four groups of four adult albino rabbits, either sex.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 50, 200, 794, and 3160 mg/kg of body weight
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Dermal irritation recorded at 24 hours and once daily thereafter for a total of 14 days
- Number of animals:
- 16
- Details on study design:
- The test substance was each administered by a single application to four groups of four rabbits each at dosage levels of 50, 200, 794, and 3160 mg/kg of body weight. The test substance was applied to the closely clipped, abraded abdominal skin of each rabbit beneath a binder of rubber dam. The trunk of each animal was then wrapped in gauze and adhesive tape, and the animals were collared to prevent ingestion of the compound. After an exposure period of 24 hours, the binders and collars were removed, and the abdominal skin was cleansed with corn oil to remove any compound residue.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #7
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #8
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #9
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #10
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #11
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #12
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #13
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #14
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #15
- Time point:
- 24 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #16
- Time point:
- 24/48/72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: desquamation
- Basis:
- other: Single rabbit not identifed by number
- Time point:
- other: days 5 and 6
- Reversibility:
- fully reversible
- Remarks:
- The observation of desquamation was noted on only two days, but not on later days of the observation period.
- Remarks on result:
- other: desquamation
- Remarks:
- desquamation in one rabbit on two days was noted in the report, but the rabbit number was not identified
- Irritant / corrosive response data:
- Skin irritation was slight and consisted of erythema (moderate in two animals at 3160 mg/kg) in all animals at 24 hours which persisted for two to six days. Desquamation was observed in one "low level" animal on Days 5 and 6.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results indicate the test substance does not meet the criteria for skin irritation classification.
- Executive summary:
Four groups of four New Zealand White rabbits (identified as males and females, but not with specified distribution) were exposured to 50, 200, 794, and 3160 mg/kg body weight of the test substance on abraded skin for 24 hours under occlusive conditions. Observations of the skin condition were made at 24 hours and daily thereafter for up to 14 days. Mild erythema was noted in all exposed animals at the first examination (24 hour time point), but did not increase in severity or duration with dose. All signs of skin irritation were resolved within six days. The results indicate that exposure to the test substance under conditions more extreme than current guidelines produced mild skins of skin irritation which were fully reversed during the observation period. On that basis the substance does not meet criteria for classification as a skin irritant.
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