Registration Dossier
Registration Dossier
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EC number: 810-753-4 | CAS number: 1374639-78-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb - June 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- ca. 0.246 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 0.246 mg/L
- Incubation duration:
- ca. 5 d
- Temp.:
- 20 °C
- pH:
- >= 7 - <= 7.1
- Details on results:
- The coefficient of variation (CV) (n = 10) was ≤ 30% at both flow rates. It demonstrated that the system was equilibrated at all flow rates.
The maximum difference (MD) on the mean values of the samples at both flow rates was also ≤ 30%. Based on this, the water solubility of the test substance is given as the mean value of these measurements.
The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates.
No test substance was detected in the samples from the blank column. - Conclusions:
- The column elution method was applied for the determination of the water solubility of LEE011-A3.
The water solubility of the test substance at 20°C was 0.246 mg/l.
The pH of the aqueous samples was 7.0 – 7.1.
Reference
Description of key information
The column elution method was applied for the determination of the water solubility of LEE011-A3.
The water solubility of the test substance at 20°C was 0.246 mg/l.
The pH of the aqueous samples was 7.0 – 7.1.
Key value for chemical safety assessment
- Water solubility:
- 0.246 mg/L
- at the temperature of:
- 20 °C
Additional information
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