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EC number: 213-322-3 | CAS number: 937-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute toxicity study the substance was administered to Wistar rats (5 animals/sex/dose) by oral gavage at a dose level of up to 2500 mg/kg bw (single administration). The oral LD50 is calculated to be 1807 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Main test was started on May 18, 1987 and terminated on June 1, 1987.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- other: OECD 401: Acute oral toxicity
- Limit test:
- no
- Specific details on test material used for the study:
- The specific details on the test material used for this study were as follows:
A 100 g sample of the test substance was received from the sponsor on April 9, 1987.
Batch number: 04.87.03.0067.
The chemical and physical properties were stated to be:
Content of active ingredient: 48.9 %
Diluting agent: water, 43.8 %
Nature and quantity of impurities: m-chlorobenzoic acid, 7. 3 %
Melting point: about 363 °K
Density: bulk- about 610 kg/m^3 - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals:
Young adult, about 9 weeks old, albino rats were used. They were Wistar outbred rats (Bor:WISW) obtained from a colony, maintained under SPFconditions at the Breeding Centre for Laboratory Animals, F. Winkelmann GmbH, Borchen, F.R. Germany. The body weights of the males varied from 188 to 237 g, those of the females from 132 to 160 g. The animals were kept under the environmental conditions of the Institute's animal house for about 3 weeks prior to the test.
Housing and maintenance:
The rats were housed in groups of five, males and females separated, in stainless steel cages with wire-screen bottom and front, in a room ventilated with about 10 air changes per hour and maintained at 22 ± 2°C. Relative humidity was between 40 and 60 per cent, lighting was artificial with a sequence of 12 hours light, 12 hours dark. Tap water was freely available at all times by means of an automatic watering system. The rats had free access to the Institute's cereal based, open formula diet for rats and mice, except in the overnight period before treatment till 4 hours after treatment when food was withheld. The diet is analyzed regularly for nutrients and contaminants. Tap water is analyzed regularly for contaminants. - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was given orally by gavage as an aqueous suspension in single doses of 1200, 1440, 1730, 2080 or 2500 mg substance per kg body weight to groups of 5 males and 5 females. For each dose level a suspension was prepared to administer a constant volume of 10 ml/kg body weight to all rats.
- Doses:
- 1200, 1440, 1730, 2080 or 2500 mg substance per kg body weight
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- not specified
- Details on study design:
- After treatment, the rats were observed frequently for signs of intoxication during the first 4 hours and thereafter, at least once daily throughout an observation period of 14 days. The individual body weights of the rats were recorded on day 0, 7 and 14. At the end of the observation period, the surviving rats were killed and examined grossly.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 807 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 457 - <= 2 241
- Mortality:
- Deaths occurred between 6 hours and 3 days after dosing.
Number of mortalities per dose per group:
At 1200 mg/kg bw: males = 0 females = 2
At 1440 mg/kg bw: males = 0 females = 3
At 1730 mg/kg bw: males = 0 females = 3
At 2080 mg/kg bw: males = 3 females = 5
At 2500 mg/kg bw: males = 3 females = 4
- Clinical signs:
- other: Within a few hours after treatment, the rats showed sluggishness, piloerection and pallor discolouration of the skin. Later on encrustations around eyes and nostrils were observed. Signs of tremors or phonation were observed in a few rats.
- Gross pathology:
- Macroscopic examination at autopsy of the rats did not reveal any treatment related gross alteration.
- Other findings:
- After treatment with the test substance, the survivors recovered and looked quite healthy throughout the remaining part of the observation period.
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- LD50 = 1807 mg/kg BTW
- Conclusions:
- The oral LD50 of m-chloroperoxybenzoic acid was calculated to be 1807 mg per kg body weight with 1457 and 2241 as the 95% confidence limits. Therefore, the test substance can be classified as slightly toxic (Hodge, H.C. and J.H. Sterner, Ind. Hyg. Assoc. Quart. 10 (1949) 93) .
- Executive summary:
1. The acute oral toxicity of m-chloroperoxybenzoic acid was examined in rats.
2. The test substance was given by gavage as aqueous suspensions in single doses of 1200, 1440, 1730, 2080 or 2500 mg per kg body weight to groups
of 5 males and 5 females.
3. Within a few hours after treatment, the rats showed sluggishness, piloerection and pallor discolouration of the skin. Later on encrustations around eyes and nostrils were observed. Signs of tremors or phonation were observed in a few rats. Deaths occurred between 6 hours and 3 days after dosing. Then the survivors recovered and looked quite healthy throughout the remaining part of the observation period.
4. The oral LD50 of the test substance was calculated to be 1807 mg per kg body weight with 1457 and 2241 as the 95% confidence limits.
Reference
Dose applied and mean body weights of each group at Days 0, 7 and 14:
Dose |
Mean body weight (g) on Day |
||||||
|
|
Males |
Females |
||||
Suspension (ml/kg) |
Substance (mg/kg) |
0 |
7 |
14 |
0 |
7 |
14 |
10.0 |
2500 |
210 |
243 |
282 |
148 |
151 |
191 |
10.0 |
2080 |
217 |
231 |
272 |
144 |
- |
- |
10.0 |
1730 |
215 |
227 |
240 |
147 |
171 |
188 |
10.0 |
1440 |
218 |
240 |
254 |
139 |
147 |
169 |
10.0 |
1200 |
213 |
234 |
253 |
143 |
156 |
176 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 807 mg/kg bw
- Quality of whole database:
- Sufficient to address requirements.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the findings of a reliable acute oral toxicity study conducted on the substance, classification of the substance is justified.
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