Registration Dossier
Registration Dossier
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EC number: 700-097-6 | CAS number: 847565-09-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- (1R,2S,5R)-5-methyl-2-(propan-2-yl)-N-[2-(pyridin-2-yl)ethyl]cyclohexanecarboxamide
- EC Number:
- 700-097-6
- Cas Number:
- 847565-09-7
- Molecular formula:
- C18H28N2O
- IUPAC Name:
- (1R,2S,5R)-5-methyl-2-(propan-2-yl)-N-[2-(pyridin-2-yl)ethyl]cyclohexanecarboxamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aq methyl cellulose
- Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- one group of 3 females at dose of 2000mg/kg bw
two groups of 3 females at dose of 300 mg/kg bw - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 300 - 2 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this test, Evercool 190 was classified as Category 4 under the Globally Harmonised Classification Systemand will require labelling with the risk phrase R22 "Harmful if swallowed"in accordance with Commission Directive 2001/59/EC
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