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EC number: 604-247-0 | CAS number: 141719-29-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 June - 14 October 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- [2-(4-chlorobutyl)cyclopenta-2,4-dien-1-yl](cyclopenta-2,4-dien-1-yl)iron
- EC Number:
- 604-247-0
- Cas Number:
- 141719-29-1
- Molecular formula:
- C14H17ClFe
- IUPAC Name:
- [2-(4-chlorobutyl)cyclopenta-2,4-dien-1-yl](cyclopenta-2,4-dien-1-yl)iron
- Test material form:
- liquid
- Details on test material:
- Appearence: brown-red liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: SNPE / LD 2332
- Appearence: brown-red liquid
- Name of test item: CL 1038
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: refrigerated under nitrogen
- Solubility and stability of the test substance in the solvent/vehicle: soluble in common solvents (acetone, hexane, chlorinated solvents)
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Crl:CD (SD) BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Saint Aubin les Elbeuf, France
- Females (if applicable) nulliparous and non-pregnant: yes
- Weight at study initiation: 142 ± 4 g for males; 124 ± 3 g for females
- Fasting period before study: 18 h before administration
- Housing: 5 of the same sexe/cage; polycarbonate cage
- Diet (e.g. ad libitum): ad libitum (rats - souris entretien; A 04 C)
- Water (e.g. ad libitum): ad libitum (0.22 µm filtered water)
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 50 ± 20 %
- Air : filtered with absolute-type filters
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- 300
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: required amount for the dose
- Amount of vehicle (if gavage): administration volume of 10 mL/kg bw
- Lot/batch no. (if required): 82202
- Provider: Prolabo, Paris, France
- Appearence: colorless liquid
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 500, 800, 1400, 1100, 2500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs are followed frequently during the first hours following the administration and then daily. Mortality is recorded twice daily. Bodyweight is measured just before administration, and on Days 5, 8 and 15.
- Necropsy of survivors and dead animals is performed - Statistics:
- LD50 was calculated by the Finney method. The 95% confidence interval was calculated according to the Fieller method.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 211 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 066 - <= 1 385
- Mortality:
- See table below
- Clinical signs:
- other: The major dose-related clinical signs were: sedation, hypokinesia, piloerection, muscle tremors, dyspnoea, lateral decubitus, ocular secretions and ptosis. These signs were observed 30 min after administration for 4 to 6 days, depending on the dose.
- Gross pathology:
- No anomalies recorded in animals sacrificed at the end of the observation period.
Any other information on results incl. tables
Mortality in males and females:
Dose (mg/kg bw |
Day 1 |
Day 2 |
Day 3 |
Day 4 |
Day 5 |
Day 6 |
Day 7 |
Day 15 |
500 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
800 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1100 |
0 |
0 |
0 |
1 |
2 |
3 |
3 |
3 |
1400 |
0 |
0 |
1 |
1 |
2 |
6 |
8 |
8 |
2500 |
0 |
0 |
1 |
6 |
8 |
10 |
10 |
10 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the test conditions, the LD50 in males and females rats of the test item was calculated to be 1211 mg/kg bw. This leads to classification of the substance as category 4 (H302) for acute oral toxicity according to CLP Regulation (EC) N° (1272-2008) and GHS criteria.
- Executive summary:
In a GLP study conducted according to OECD guideline 401, groups of 5 male and 5 female Sprague-Dawley rats were given a single dose of the test item suspended in PEG300 at the doses of 500, 800, 1400, 1100, 2500 and 5000 mg/kg bw. All animals were observed for mortality, clinical signs and bodyweights for 14 days and survivors were sacrificed for macroscopic examination.
The major dose-related clinical signs were: sedation, hypokinesia, piloerection, muscle tremors, dyspnoea, lateral decubitus, ocular secretions and ptosis. These signs were observed 30 min after administration for 4 to 6 days, depending on the dose. Normal evolution was observed at 500, 800 and 1100 mg/kg bw. A slight and important decrease in bodyweight is recorded on Day 5 at 1400 and 2500 mg/kg bw, respectively. Mortality was observed from 1100 mg/kg bw and above, in both sexes.
Under the test conditions, the LD50 in males and females rats of the test item was calculated to be 1211 mg/kg bw. This leads to classification of the substance as category 4 (H302) for acute oral toxicity according to CLP Regulation (EC) N° (1272-2008) and GHS criteria.
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