Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 825-403-6 | CAS number: 2060541-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Principles of method if other than guideline:
- The test item was tested for biodegradability according to the OECD-Test Guideline 301 B "Ready Biodegradability: Modified Sturm Test" and to the 6th Amendment of the Council Directive 67/548/EEC.
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: See below
- Details on inoculum:
- Prior to use activated sludge from the sewage plant (Frankfurt/M.-Niederad) was washed twice with mineral nutrient solution (test medium) as
described in the OECD Guideline 301 B to eliminate organic and toxic components from the sludge. After resuspension in mineral nutrient
medium the sludge was aerated by means of compressed humidified air for approximately four hours then allowed to settle for 30 to 60 minutes
and filtered. The filtrate was used as inoculum (1% of the final volume of the test solution). - Duration of test (contact time):
- 28 d
- Initial conc.:
- 5 mg/L
- Based on:
- test mat.
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- The test chemical and polyvalent inoculum and mineral nutrient solution (sewage microorganisms from a sewage plant working without industrial wastes) were incubated together for a period of 28 days in the dark at 22 +/- 1 °C.
The biodegradation observed in the course of the study was determined as a percentage of the amount of CO2 that the test chemical could have
theoretically produced. This is based on the assumption that the organic carbon of the test chemical would have been quantitatively converted to
C02. For full composition see attached report. - Reference substance:
- benzoic acid, sodium salt
- Test performance:
- Temperature was measured on working days and documented. Values were within the range of 21 ± 2 °C.
The C02 evolution of the blank slightly exceeded the value of 50 mg/3 L indicated in the guideline OECD 301 B of 1981 but it is fully within the range of 40 mg/L indicated by the latest version adopted in July 1992. The test is valid since sodium benzoate as reference was degraded to more than
60 % within 28 days (observed value: 87.7% within 9 days). - Parameter:
- % degradation (CO2 evolution)
- Value:
- 122.9
- Sampling time:
- 28 d
- Remarks on result:
- other: 5 ppm
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 62.2
- Sampling time:
- 28 d
- Remarks on result:
- other: 10ppm
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 32.3
- Sampling time:
- 28 d
- Remarks on result:
- other: 20ppm
- Results with reference substance:
- sodium benzoate as reference was degraded to more than 60 % within 28 days (observed value: 84.2% within 8 days).
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The substance is considered readily biodegradable.
- Executive summary:
The substance is considered readily biodegradable.
Reference
Biodegradation calculation
Determination of Biodegradation: Degradation was calculated as a percentage of the theoretical CO2 that should have been produced from the organic matter of the substance by complete oxidation. The CO2 being generated were calculated to the nearest 0.01 mg and biodegradation values were rounded to the nearest 0.1 percent.
The TKO, was calculated to be 0.559 mg CO,/mg test chemical determined as TOC of the test substance
Biodegredation therefore equals = mg Co2 produced x 100
mg of test chemical added x ThC02
Description of key information
Sodium cocoamphopolycarboxyglycinate was biodegraded by 35% at day 28 in the Closed Bottle test. This test substance should therefore not be classified as readily biodegradable. In the prolonged Closed Bottle test sodium cocoamphopolycarboxyglycinate was biodegraded 39% at day 60. The biodegradation curve levels off between 20 and 60% biodegradation suggesting partial degradation of the test substance. The lack of complete biodegradation in the Closed Bottle test does not mean that part of the test substance is recalcitrant in nature because the stringency of the test procedures could account for the recalcitrance in the Closed Bottle test.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable, not fulfilling specific criteria
- Type of water:
- freshwater
Additional information
There are two ready biodegradability test results available for Sodium cocoamphopolycarboxy glycinate. One OECD 301D enhanced test where is was concluded that the test substance should not be considered readily biodegradable based on 35% biodegradation on day 28. The prolongation of this study resulted in 39% biodegradation on day 60 suggesting partial degradation of the test substance. The result of this study will be used for risk assessment and classification because the results of the study from Danneberg were difficult to interpret .
In this study from Danneberg (1993) the ready biodegradability was evaluated in a Zahn Wellens test according to OECD TG 301B. 122.9% biodegradation was observed based on CO2 evolution at 5 ppm test substance. Based on the results of this study the substance may be evaluated as readily biodegradable. Lower percentages of biodegradation were observed at 10 and 20 ppm test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.