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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 215-355-9 | CAS number: 1323-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific expert review of experimental data deemed reliable and valid
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: review of experimental data by an expert panel
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific expert review of experimental data deemed reliable and valid
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Experimental and estimated data (from (Q)SAR and Categories) was reviewed, and expert judgement was applied for determining if human health or environmental effects existed which would lead to reconsidering the appropriateness of listing according to Annex IV criteria.
- GLP compliance:
- no
- Species:
- rat
- Sex:
- not specified
- Route of administration:
- other: estimated that the route would be oral gavage
- Details on study design:
- Extrapolation from experimental repeated dose toxicity study where NOAEL > 5000 mg/kg bw/d (NTP, 1992).
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Expert judgement: LD50 > 5000 mg/kg bw (read across from repeat dose toxicity).
- Other findings:
- Extracted from the (M)SDS of the product: "May cause digestive tract irritation. It is considered a purgative and stimulates smooth muscle of the digestive tract."
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- After review of the repeated dose toxicity study of 1992 (NTP), the expert panel evaluating REACH Annex IV listings estimated that the LD50 of castor oil is greater than 5000 mg/kg bw.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Experimental and estimated data (from (Q)SAR and Categories) was reviewed, and expert judgement was applied for determining if human health or environmental effects existed which would lead to reconsidering the appropriateness of listing according to Annex IV criteria.
- GLP compliance:
- no
Test material
- Test material form:
- solid: flakes
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: estimated that the route would be oral gavage
- Details on study design:
- Extrapolation from experimental repeated dose toxicity study where NOAEL > 5000 mg/kg bw/d (NTP, 1992).
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Expert judgement: LD50 > 5000 mg/kg bw (read across from repeat dose toxicity).
- Other findings:
- Extracted from the (M)SDS of the product: "May cause digestive tract irritation. It is considered a purgative and stimulates smooth muscle of the digestive tract."
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- After review of the repeated dose toxicity study of 1992 (NTP), the expert panel evaluating REACH Annex IV listings estimated that the LD50 of castor oil is greater than 5000 mg/kg bw. This supports the suggestion that a related substance, GMHS, is acutely nontoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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