Registration Dossier
Registration Dossier
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EC number: 237-580-1 | CAS number: 13846-31-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 June 2017 - 22 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The test is preferably run at 20 ±0.5°C, however the highest recorded during testing was 0.8°C. Due to technical reasons the equilibration time at 20°C was 96 hrs (not 24 hrs) as per the study plan. These deviations had no effect on study results.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The test is preferably run at 20 ±0.5°C, however the highest recorded during testing was 0.8°C. Due to technical reasons the equilibration time at 20°C was 96 hrs (not 24 hrs) as per the study plan. These deviations had no effect on study results.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Name: MDAC
- Source: Osaka Soda Co. Ltd
- Lot/batch No.of test material: 40201
- Expiration date of test material: 26 January 2019
- Description: Colourless liquid
- Purity: 99.2%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Controlled room temperature, protected from light - Key result
- Water solubility:
- ca. 110 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- ca. 1 d
- Temp.:
- 20 °C
- pH:
- ca. 4.54 - ca. 4.7
- Details on results:
- Calibration: Concentration levels: 0.5, 1, 2, 5, 10, 25 and 50 μg/mL. The calibration graph was calculated by linear regression.
pH samples variation range 4.54 - 4.70.
Samples were analysed using HPLC.
Based on the measured concentrations, test mixtures were homogeneous and the whole amount of added MDAC was dissolved. - Conclusions:
- The water solubility of MDAC was determined to be 110 ±2.72 μg/mL (95% confidence interval) at 20°C ±0.8°C using the shake-flask method.
Reference
Description of key information
The water solubility of MDAC was determined to be 110 ±2.72 μg/mL (95% confidence interval) at 20°C ±0.8°C using the shake-flask method.
Key value for chemical safety assessment
- Water solubility:
- 110 mg/L
- at the temperature of:
- 20 °C
Additional information
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