2-isopropyl-9H-thioxanthen-9-one

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 July 2017 to 14 July 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 113 (Thermal Stability)

Version / remarks:

1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Key result

Temp.:

20 °C

Vapour pressure:

0 Pa

Key result

Temp.:

25 °C

Vapour pressure:

0 Pa

Key result

Temp.:

50 °C

Vapour pressure:

0.002 Pa

The vapour pressure was measured in the temperature range of 58 to 92 °C. The measured vapour pressure values together with the measured temperatures are listed in Table 1.

Table 1: Results of the effusion method

No.	Temperature (°C)	Vapour pressure (Pa)
1	58	4.12 x 10^-3
2	63	7.62 x 10^-3
3	68	1.20 x 10^-2
4	73	2.03 x 10^-2
5	78	3.08 x 10^-2
6	83	5.22 x 10^-2
7	88	9.66 x 10^-2
8	92	1.54 x 10^-1

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation;

Log10p = A + (B/T) = A + (B/ (C +))

can be derived by regression of the data points to

A = 14.06,

B = -5448.85 and

C = 273.15.

The vapour pressure of the test material calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C is shown in Table 2.

Table 2:Calculated vapour pressure values for 20, 25 and 50 °C

Temperature (°C)	Vapour pressure (Pa)
20	3.0 x10^-5
25	6.1 x10^-5
50	1.6 x10^-3

Conclusions:

Under the conditions of this study the vapour pressure of the test material was 3.0 x10^-5 at 20 °C, 6.1 x10^-5 at 25 °C and 1.6 x10^-3 at 50 °C.

Executive summary:

The vapour pressure of the test material was determined in accordance with the standardised guidelines OECD 104 and EU Method A.4 under GLP conditions.

The test was performed using the effusion method with a vapour pressure balance. The vapour pressure was determined for eight temperatures in the temperature range 15 to 150 °C and in the pressure range 10^-3 to 1 Pa.The vapour pressure of the test material was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C.

Under the conditions of this study the vapour pressure of the test material was 3.0 x10^-5 at 20 °C, 6.1 x10^-5 at 25 °C and 1.6 x10^-3 at 50 °C.

Description of key information

Under the conditions of this study the vapour pressure of the test material was 3.0 x10^-5 at 20 °C, 6.1 x10^-5 at 25 °C and 1.6 x10^-3 at 50 °C.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of the test material was determined in accordance with the standardised guidelines OECD 104 and EU Method A.4 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The test was performed using the effusion method with a vapour pressure balance. The vapour pressure was determined for eight temperatures in the temperature range 15 to 150 °C and in the pressure range 10^-3 to 1 Pa.The vapour pressure of the test material was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C.

Under the conditions of this study the vapour pressure of the test material was 3.0 x10^-5 at 20 °C, 6.1 x10^-5 at 25 °C and 1.6 x10^-3 at 50 °C.