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EC number: 211-941-3 | CAS number: 717-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 21, 2015 to Jul 3, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: HJ/T 153-2004. The guidelines for the testing of chemicals [S]. Beijing: State Environmental Protection Administration, 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CRC-MEP. The Guidelines for the Testing of Chemicals, Effects on Biotoc Systems [M]. 2nd edition. Beijing: China Environment Press. 2013: 30-36
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: GB/T 27861-2011, Chemicals-Fish acute toxicity test, Beijing: SAC, 2011
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: GBff 29763-2013, Chemicals-Rare Minnow (Gobiocypris rarus) acute toxicity test Beijing: SAC, 2013
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- According to the guidelines of chemical testing good laboratory practices in China
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Lot No. 6F11027000
- Expiration date of the lot/batch: 2 years
- Purity: 96%
- Appearance: clear high boiling odorless liquid - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L
- Vehicle:
- no
- Details on test solutions:
- For the range-finding test, the test solution was prepared by directly adding appropriate amounts of H6362 into dilution water (good quality tap water dechlorinated for at least 24hrs) and facilitating its dispersion by stirring for 30 min. Vortex height set to at least 10% of static liquid height. The test solution was reported as colourless and clear.
For the limit test, water accommodated fractions (WAFs) solutions were prepared by adding the test material (0.4165 ~ 0.4168g) to the test medium (4 L) in glass aspirator bottles, to a nominal concentration of 100 mg/L. The test solution was mixed for 24hrs then allowed to settle for 1 hr at room temperature. The aqueous portion (WAFs solution) was then removed through the outlet of the aspirator stirring bottle without further filtration. - Test organisms (species):
- other: Gobiocypris rarus
- Details on test organisms:
- TEST ORGANISM
- Common name: Rare minnow, Gobiocypris rarus
- Source: Batch No. F20150215G, commercial fish supplier of Institute of Hydrobiology, Chinese Academy of Sciences
- Age at study initiation: fry stage
- Length at study initiation: 2.32 cm, RSD 7.37%
- Weight at study initiation: 0.257 g, RSD 7.53%
ACCLIMATION
- Acclimation period: 7 days
- Acclimation conditions: same water quality and temperature as to be used in the test
- Type and amount of food during acclimation: Proprietary fish food (crude protein >36.0%, crude fibre <3.0%, crude fat >2.0%, crude ash <12.0%)
- Feeding frequency during acclimation: Daily
- Health during acclimation: No mortalities observed
FEEDING DURING TEST
No, fish held without food for apprx 24-hrs before being placed into test vessels - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Mortalities of fish were observed at 24, 48, 72, and 96-hrs
- Hardness:
- 136-143 mg (CaCO3)/L
- Test temperature:
- 23.2-23.4 °C
- pH:
- 7.98-8.07
- Dissolved oxygen:
- 74-93% the air saturation, no aeration
- Nominal and measured concentrations:
- Range-finding test: 1.00, 10.0, 100 mg/L (nominal)
Limit test: 100 mg/L (nominal); 0.088 mg/L (mean measured) - Details on test conditions:
- TEST SYSTEM
- Test vessel: tank
- Material, size, headspace, fill volume: contained 4L of test solution
- Aeration: No
- No. of organisms per vessel: 7 fish
- No. of vessels per concentration: 3
- No. of vessels per control: 3
- Biomass loading rate: 0.5-0.6 g fish (ww)/L of test medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Good quality tap water, dechlorinated for at least 24-hrs
- Total organic carbon: 1.3 mg/L
- Particulate matter: visible substance “N/A”
- Metals: As, Cd, Pb, Hg, Co, Ni, Cu, Cr6+, Fe, Zn, Ag. Analyzed concentrations of As, Cd, Pb, and Hg either equal to or exceed the acceptable values (referenced in the OECD TG 203)
- Pesticides: malathion, methyl parathion, parathion monitored
- Intervals of water quality measurement: pH, DO, temp. recorded daily
OTHER TEST CONDITIONS
- Photoperiod: 16-hrs daily
- Light intensity: 1000 lux to 1500 lux
EFFECT PARAMETERS MEASURED:
- Mortality, inactivity, abnormal swimming patterns, other abnormal behavior. Observations made at 24, 48, 72 and 96-hr.
TEST CONCENTRATIONS
- Range finding study: Spacing factor for test concentrations: 10
- Range finding study: Test concentrations: 1.00, 10.0, 100 mg/L
- Results used to determine the conditions for the definitive study (limit test): 100 mg/L - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.088 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Nominal conc. = 100 mg/L
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: Nil (normal behavior reported)
- Observations on body length and weight: Not specified
- Mortality of control: 0
- Other adverse effects control: Not specified
- Abnormal responses: Nil - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- LC50: 24-hr LC50 = 291 mg/L - Sublethal observations / clinical signs:
Results reported as:
96 h-LC50 > 100 mg/L WAFs (measured water samples concentration was 0.088 mg/L)
96 h-LC0 = 100 mg/L WAFs (measured water samples concentration was 0.088 mg/L)
Validation of study:
- pH values of control mediums and test mediums: 7.98-8.07; Criteria met: 6.0~8.5
- DO range: 74-93% of the air saturation; Criteria met: > 60% air saturation
- Total hardness: 136-143 mg (CaCO3)/L; Criteria met: 10~250 mg (CaCO3)/L
- Temperature range: 23.2-23.4 °C; Criteria met: 23±2 °C
- 24-hr LC50 of positive control: 291 mg/L; Criteria met: 24-hr LC50 = 200-400 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the static conditions of the test study, the acute toxicity of the test item to Rare minnow (Gobiocypris rarus) over a 96-hr test period resulted in an LC50 result of > 100 mg/L WAF and an LC0 = 100 mg/L WAF.
- Executive summary:
The acute toxicity of 1,3,5-triisopropylbenzene was tested under static conditions in a 96 -hour toxicity study on the Rare minnow (Gobiocypris rarus) in a limit test equivalent to OECD TG 203. Based on nominal concentrations, the 96-h LC50 was determined to be > 100 mg/L and the 96-h LC0 was 100 mg/L.
Reference
Description of key information
The acute toxicity of 1,3,5-triisopropylbenzene was tested under static conditions in a 96 -hour toxicity study on the Rare minnow (Gobiocypris rarus) in a limit test equivalent to OECD TG 203. Based on nominal concentrations, the 96-h LC50 was determined to be > 100 mg/L and the 96-h LC0 was 100 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
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