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Diss Factsheets
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EC number: 947-744-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980-02-12 to1980-02-26
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Test was performed as limit test in 10 females.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Fatty acids, C16-18 (even numbered), esters with 1,2,3-propanetriol and oligomers, ethoxylated
- IUPAC Name:
- Fatty acids, C16-18 (even numbered), esters with 1,2,3-propanetriol and oligomers, ethoxylated
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Physical state: white waxi paste
Test animals
- Species:
- rat
- Strain:
- other: Wistar
- Remarks:
- Hoe WISKf(SPF71) breading at Hoechst company
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- weight: 174 to 191 g
Mean weight: 180.5 +- 4.93g
- Housing:
- Diet (e.g. ad libitum): ALTEOMIN GmbH, Lage /Lippe, Germany)
- Water (e.g. ad libitum): Tap water
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Remarks:
- at about 33°C
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 % solution (i.e. 25g/ ad 100 mL) in sesame oil at 33 ° C. - Doses:
- 10 000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: once weekly weighing
- Necropsy of survivors performed: yes, gross pathology examination - Statistics:
- n.a.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- other: limit dose
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- n.a.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the available results of an acute oral toxiicty study in female Wistar rats a clear LD50 value could not be determined but the LD50 is assumed greater than 10000 mg/kg
- Executive summary:
In order to evaluate the acute oral toxicity of Hostacerin DGSB an acute orl toxicity test was performed. The test item was applied to 10 female Wistar rats by oral gavage at a concentration of 10000 mg/kg bw in sesame oil as vehicle (25g of test item was disolved in 100 ml of sesame oile at 33 °C). Food was restricted 16 hours prior and 2 hour after application of test item. Tap water was allowed ad libitum. The animals were observed for any clinical sign of toxicity for a period of 14 days. Body weight was taken weekly during the 14 day observation period.
No clinical signs and no mortality was observed during the 14 day observation period. At the end of the observation period the rats were sacrficed by CO2 and necropsied. There were no gross pathological effect observed. The determination of an LD 50 was not possibel but it is assumed to be greater than 10000 mg/kg.
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