Reaction mass of undec-8-enal and undec-9-enal and undec-10-enal

Partition coefficient

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2/1/2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The information is derived from a reliable non-GLP in-house study according to OECD TG 117 (HPLC).

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Key result

Type:

log Pow

Partition coefficient:

4.6

Temp.:

25 °C

Remarks on result:

other: pH not provided in the study report

Details on results:

The pH is assessed not to be critical based on the absence of acidic and basic structural features of Intreleven aldehyde and in its molecular structure.

Conclusions:

The partition coefficient of Intreleven aldehydehas been determined as log P = 4.6 at 25°C in a study equivalent to OECD Guideline 117 (HPLC method) in a reliable non-GLP study.

Executive summary:

The partition coefficient of Intreleven aldehyde has been determined as log P = 4.6 at 25°C in a study equivalent to OECD Guideline 117 (HPLC Method).

Reference 2

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14-02-2017 - 01-04-2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

slow-stirring method

Partition coefficient type:

octanol-water

Analytical method:

gas chromatography

Key result

Type:

log Pow

Partition coefficient:

4.47

Temp.:

25 °C

Remarks on result:

other: vessel 1, standard deviation: 1.35 x 10 ^-2, variance 1.81 x 10^-4

Key result

Type:

log Pow

Partition coefficient:

4.47

Temp.:

25 °C

Remarks on result:

other: vessel 2, standard deviation: 2.00 x 10 ^-2, variance 4.02 x 10^-4

Key result

Type:

log Pow

Partition coefficient:

4.47

Temp.:

25 °C

Remarks on result:

other: vessel 3, standard deviation: 1.55 x 10 ^-2, variance 2.39 x 10^-4

  The results are summarized in the following table:

Vessel	1	2	3
Mean log10Pow	4.47	4.47	4.47
Standard Deviation	1.35 x 10^-2	2.00 x 10^-2	1.55 x 10^-2
Variance	1.81 x 10^-4	4.02 x 10^-4	2.39 x 10^-4

 

Weighted average log₁₀P_ow  : 4.47

Partition coefficient (P_ow)  : 2.92 x 10⁴

Variance weighted log₁₀P_owstandard deviation  : 1.48 x 10^-3

 

     

 

Conclusions:

The partition coefficient (Pow) of the test item has been determined to be 4.47 at a test temperature of 25.0 ± 0.5°C.

Executive summary:

The partition coefficient (Pow) of the test item has been determined to be 4.47 at a test temperature of 25.0 ± 0.5°C, using the slow-stirring method designed to be compatible with Method 123 of the OECD guidelines for testing of Chemicals, 23 March 2006.

Description of key information

The partition coefficient (Pow) of Intreleven aldehyde has been determined to be 4.47 at a test temperature of 25.0 ± 0.5°C, using the slow-stirring method designed to be compatible with Method 123 of the OECD guidelines for testing of Chemicals, 23 March 2006. The partition coefficient of Intreleven aldehyde was determined as log P = 4.6 at 25°C in a supporting study equivalent to OECD Guideline 117 (HPLC Method).

                   

Key value for chemical safety assessment

Log Kow (Log Pow):

4.47

at the temperature of:

25 °C