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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Studie performed according to OECD and GLP guidlines
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
Principles of method if other than guideline:
-
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Reaction mass of [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium bromide and [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium chloride
IUPAC Name:
Reaction mass of [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium bromide and [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium chloride

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
other: The contralateral flank was similarly prepared (but without test substance and vehicle) to act as a procedural control.
Duration of treatment / exposure:
4 h
Observation period:
72 h
Number of animals:
3

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
1
Reversibility:
fully reversible within: 24 h
Other effects:
-

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Wittigesterhalogenid need not be labelled as a skin irritant.
Executive summary:

Wittigesterhalogenid was applied onto shaved skin of three male albino rabbits using semi-occlusive dressings for 4 hours, followed by four observations at approximately 1, 24, 48 and 72 hours after removal of the dressings and remaining test substance.

Under the conditions of this study, Wittigeserhalogenid resulted in very slight erythema in two of the three animals, which had resolved within 24 hours after exposure. No corrosive effect occurred on the skin in any of three rabbits. In the area of application, yellow staining of the treated skin by Wittigesterhaolgenid was observed on day 1.

No signs of systemic intoxication were observed during the study period.