Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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Reaction mass of Phosphonium, (4-ethoxy-3-methyl-4-oxo-2-butenyl)triphenyl bromide [4-Ethoxy-3-methyl-4-oxo-2-butenyl]-triphenylphosphonium bromide and Phosphonium, (4-ethoxy-3-methyl-4-oxo-2-butenyl)triphenyl chloride [4-Ethoxy-3-methyl-4-oxo-2-butenyl]-triphenylphosphonium chloride[4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl[4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)phosphonium bromide
EC number: 900-131-1 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study performed according to OECD and GLP guidelines
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium bromide and [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium chloride
- IUPAC Name:
- Reaction mass of [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium bromide and [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 400 mg/kg , 200 mg/kg
- No. of animals per sex per dose:
- 5 per sex (400 mg/kg)
3 per sex (200 mg/kg) - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 200 - < 400 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is toxic in case of swallowing
- Executive summary:
The acute oral toxicity of C5-Wittigesterchlorid/bromid was assessed in Wistar rats of both sexes, including a 14-day observation period.
After single dose administration (oral) of 400 mg/kg and 200 mg/kg of C5-Wittigesterchlorid/bromid 6/10 animals resp. 1/6 animals died within a few hours after dosing. The high-dose animals were sedated after treatment. Severe liver necrosis was observed at low- and high-dose. C5-Wittigesterchlorid/bromid is considered as "toxic in case of swallowing" according to the EEC guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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