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EC number: 908-205-5
CAS number: -
MTDID 22327 is manufactured in the EU for export. Releases are
anticipated to be primarily to the atmospheric compartment. This
compound is unlikely to partition to terrestrial or aquatic compartments
from the atmosphere based on partition coefficients. The experimental
vapor pressure (213 mm Hg at 20 °C) and read across values for Henry’s
Law constant (range: 171 - 1021 atm∙m³/mol for other constituents, >1021
– 4020 atm∙m³/mol for tertiary amines, at 22 °C) suggest that MTDID
22327 is expected to partition from wet or dry terrestrial surfaces into
the atmosphere. Only negligible amounts of MTDID 22327 are expected to
be present in aquatic systems or soils.
The logarithm of the organic carbon normalized adsorption coefficient
(log Koc) is used to describe the tendency for a substance to partition
from water to soils or suspended solids. The water solubility of MTDID
22327 is slight (range for predominant constituents, 0.679 μg/L to 758
µg/L at ca. 23 - 24 °C) and the log Koc range was calculated (1) to be
3.6 - 5.1 based on read across log Kow values for predominant
constituents. Based on these data MTDID 22327 is anticipated to
partition from water to soils and suspended solids for a short period of
time. Given the rapid partitioning to the atmosphere from soils and from
water, the overall net partitioning will be to the atmosphere.
The logarithm of the octanol air partition (log Koa) coefficient is used
to describe the tendency of a substance to partition from air into the
lipid rich tissues of air breathing organisms. The calculated log Koa
values for MTDID 22327 range from 0.39 to 1.52, based on read across of
dimensionless Henry’s Law constant and Kow values. This log Koa range
indicates that MTDID 22327 has a low potential to partition from air to
the lipid rich tissues of air-breathing organisms.
Unlike most members of the category, MTDID 22327 is a UVCB consisting
mostly of perfluoro-N-methylmorpholine, a mixture of C5-C7
perfluorinated tertiary amines, and mixed perfluorohexanes. However, all
of the members of this category stem from the same manufacturing
process, have similar physicochemical properties including high vapor
pressure and low water solubility relative to the hydrocarbon analogs
(e. g., hexanes v. perfluorohexanes), and also lack any chemically
reactive groups, which forms the technical basis for the category.
Members of this category are fully fluorinated, meaning that fluorine,
rather than hydrogen, is bonded to all carbon atoms in the molecule.
Fluorine is the most electronegative of the elements (fluorine has an
electronegativity of 3.98 on the Pauling scale, as compared to 2.55 for
carbon or 2.20 for hydrogen). This electronegativity is expected to
dominate over all other aspects of substance chemistry and is the
underlying basis for similarity of substances in this category. Because
these substances exhibit similarity in their physicochemical properties
and toxicological properties in mammals, and because available data
indicates that parent molecules are not reactive toward biological
molecules and cannot undergo bioactivation or indeed any reaction by
normal enzymatic processes, they are considered to constitute a chemical
category. Data gaps for transport and distribution can therefore be
addressed by read-across between category members. Please see IUCLID
section 13 for the category justification and a matrix of
physicochemical and distribution data for members of the Perfluorinated
Organic Chemicals C5-C18 category.
(1) European Chemicals Bureau: Technical Guidance Document of Risk
Assessment, Chapter 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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