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Diss Factsheets
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EC number: 222-940-2 | CAS number: 3674-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Experimental data on mutagenicity are available for KLOB-010; nevertheless a deepening for this property has been performed.
Link to relevant study records
- Endpoint:
- genetic toxicity in vitro, other
- Remarks:
- VEGA QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
- Version / remarks:
- May 2008
- Deviations:
- not applicable
- Conclusions:
- KLOB-010 is considered as “Mutagen”, nevertheless it was not possible collecting the primary reference.
- Executive summary:
KLOB-010 is considered as “Mutagen”.
Reference
EXPERIMENTAL DATA
Experimental value is Mutagen. Model prediction is Mutagen (good reliability).
Compound SMILES: O=C(OC)C(CCl)Cl
Experimental value: Mutagen
Predicted Mutagen activity: Mutagen
Molecules used for prediction: 1
Reliability: the predicted compound is into the Applicability Domain of the model
Remarks: none
Endpoint conclusion
- Endpoint conclusion:
- no study available
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Experimental data on mutagenicity are available:
- Ames test (five Salmonella Typhimurium strains): positive with and without metabolic activation;
- Micronucleus Test: negative.
The following deepening for this property has been performed:
- Classification provided by companies to ECHA in CLP notifications this substance is suspected of causing genetic defects;
- Experimental data on mutagenicity is available in the Vega model and the substance is considered as “Mutagen”, nevertheless it was not possible collecting the primary reference;
- KLOB-010 is predicted as suspected mutagen by the Toolbox profiler (i) in vitro mutagenicity (Ames test) alerts by ISS and (ii) in vivo mutagenicity (Micronucleus) alerts by ISS give an alert for mutagenicity (Aliphatic halogen).
The others predictions on mutagenicity obtained by Vega and Danish EPA models are not reliable.
In general, the genotoxic potential is dependent on the nature, number, and position of halogen(s) and the molecular size of the compound. Moreover, biotransformation (Cytochrome P450 oxidation, glutathione (GSH) conjugation) may also play an important role in their toxicity.
Overall, available data are inconclusive for the classification of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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