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EC number: 248-813-1 | CAS number: 28065-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Oct. 2017 - 09 Mar. 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- In the Version dated 13-Apr-04
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Oleic acid, compound with (Z)-octadec-9-enylamine (1:1)
- EC Number:
- 248-813-1
- EC Name:
- Oleic acid, compound with (Z)-octadec-9-enylamine (1:1)
- Cas Number:
- 28065-97-6
- Molecular formula:
- C34H69NO2 C36H67NO2 C36H69NO2 C36H71NO2 C36H73NO2
- IUPAC Name:
- oleic acid, compound with (Z)-octadec-9-enylamine (1:1)
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- pH:
- 5
- Remarks on result:
- other: the temp. is not provided in the study report.
Any other information on results incl. tables
Retention times of test item by means of HPLC method
Table 2: Retention Times of Test Item Measurement
|
Run 1 |
Run 2 |
Substance |
tR |
tR |
# |
[min] |
[min] |
Formamide |
0.922 |
0.921 |
Oleylamine |
25.205 |
25.191 |
Oleic acid / Oleate |
29.455 |
29.477 |
The chromatograms showed additional peaks, which retard before the Oleylamine and the Oleic acid / Oleate. Due to the fact that the 2 main parts show very low UV absorptions, the other peaks were not taken under consideration for the results and discussion.
Calculation of the Partition Coefficient log Pow
Table 3: Capacity factors of the test item
|
Run 1 |
Run 2 |
||
Substance |
k |
log k |
k |
log k |
# |
[/] |
[/] |
[/] |
[/] |
Oleylamine |
26.34 |
1.42 |
26.35 |
1.42 |
Oleic acid / Oleate |
30.95 |
1.49 |
31.01 |
1.49 |
Equation of log k versus log Pow
y = 3.0673x + 2.2005
with a correlation coefficient (r2) of 0.9786.
a = 2.2005
b = 3.0673
Table 4: Calculated log Powvalue of test item
Test item |
Run 1 |
Run 2 |
average |
# |
[/] |
[/] |
[/] |
Oleylamine |
6.56 |
6.56 |
6.6 |
Oleic acid / Oleate |
6.77 |
6.78 |
6.8 |
The main parts of the test item showed a calculated log Pow value of Oleylamine of 6.6 and of Oleic acid / Oleate of 6.8 at pH 5.0.
All validity criteria were met. The correlation coefficient is above 0.9 and the difference between the two measurements is less than 0.1 log Pow units.
The calculated log Pow values of the two main parts of the test item were above the highest calibration value. Furthermore it can be expected that at lower pH the log Pow values will rise but a lower pH value does not show evaluable peaks of the test item.
Determination of the log Pow by OECD 123 (slow stirring method) can only partially be seen as an alternative, because the test item is a mixture and the analytical determination of the expected concentrations of Oleylamine as well as Oleic acid / Oleate will lead to problems with a suitable analytical method and its accuracy and recovery.
Under consideration of all of these points it is recommended that the calculated log Pow values by QSAR models of Oleylamine and Oleic acid / Oleate should be used for further calculations or statements.
According to the definition of the OECD-Test-Guideline 117 the main parts of test item show a log Pow of > 6.5 at pH 5.0.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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