Registration Dossier
Registration Dossier
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EC number: 232-504-3 | CAS number: 8060-28-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 hours
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Hop extract - CO2 extract of Humulus lupulus variety 'Cascade'. Batch number 160025. Principal components: alpha acids: 35.06% w/w; beta acids: 38.47% w/w; essential oils: 8.92% v/w
- Test organisms (species):
- activated sludge
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Conc. based on:
- act. ingr.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Study Conclusion: "The study was conducted according to the test guideline. HOP EXTRACT exhibited some respiration inhibition at 1000mg/l. The definitive test was not required by the sponsor and was, therefore, not performed. HOP EXTRACT also demonstrated no abiotic response.
The 3-hour EC50 of HOP EXTRACT to activated sludge respiration inhibition was determined to be >1000mg/l (using linear interpolation) during the preliminary study.
The NOEC for HOP EXTRACT was determined to be 100mg/l using direct observation."
Reference
Description of key information
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
The EC50 of 1000 mg/l is used for CSR
Study Conclusion: "The study was conducted according to the test guideline. HOP EXTRACT exhibited some respiration inhibition at 1000mg/l. The definitive test was not required by the sponsor and was, therefore, not performed. HOP EXTRACT also demonstrated no abiotic response.
The 3-hour EC50 of HOP EXTRACT to activated sludge respiration inhibition was determined to be >1000mg/l (using linear interpolation) during the preliminary study.
The NOEC for HOP EXTRACT was determined to be 100mg/l using direct observation."
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